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Int J Clin Exp Pathol 2013;6(6):1068-1075
Original Article
Primary central nervous system lymphoma in immunocompetent individuals: a single
center experience
Hilal Aki, Didem Uzunaslan, Caner Saygin, Sebnem Batur, Nukhet Tuzuner, Ali Kafadar, Seniz Ongoren, Buge Oz
Department of Pathology, Istanbul University, Cerrahpasa Faculty of Medicine, Istanbul, Turkey; Department of Neurosurgery, Istanbul
University, Cerrahpasa Faculty of Medicine, Istanbul, Turkey; Department of Hematology, Istanbul University, Cerrahpasa Faculty of Medicine,
Istanbul, Turkey
Received March 15, 2013; Accepted April 23, 2013; Epub May 15, 2013; Published June 1, 2013
Abstract: Primary central nervous system lymphoma (PCNSL) is defined as the involvement of brain, leptomeninges, eyes or spinal cord by
non-Hodgkin lymphoma. The role of various prognostic markers in predicting adverse outcome is debated. Objectives: To investigate the
clinical and immunohistochemical findings of immunocompetent PCNSL cases (39 cases) diagnosed at the study center, and evaluate the
influence of potential prognostic factors on overall survival (OS) of patients. Methods: Data regarding patient characteristics, neuroimaging,
pathological and immunohistochemical features and follow-up were obtained from patient records. The influence of potential prognostic
parameters on OS was investigated by log-rank test and Cox regression analysis. Results: Patients who received combined chemotherapy
and radiotherapy had a significantly better OS when compared to chemotherapy alone. Other variables included in this study were not
associated with a significant survival advantage. Conclusion: In this study, we failed to demonstrate a relationship between different
clinicopathological variables and OS of patients. Prospective studies with large patient series are needed to investigate other potential
prognostic factors. (IJCEP1303033).
Keywords: Primary central nervous system lymphoma, immunocompetent, PCNSL, prognosis, survival
Address correspondence to: Dr. Hilal Aki, Cerrahpasa Faculty of Medicine, Department of Pathology, Fatih, Istanbul, Turkey. Phone: +90 533
729 7538; Fax: +90 212 632 0050; E-mail: hilal_aki@yahoo.com.tr
Original Article
Primary central nervous system lymphoma in immunocompetent individuals: a single
center experience
Hilal Aki, Didem Uzunaslan, Caner Saygin, Sebnem Batur, Nukhet Tuzuner, Ali Kafadar, Seniz Ongoren, Buge Oz
Department of Pathology, Istanbul University, Cerrahpasa Faculty of Medicine, Istanbul, Turkey; Department of Neurosurgery, Istanbul
University, Cerrahpasa Faculty of Medicine, Istanbul, Turkey; Department of Hematology, Istanbul University, Cerrahpasa Faculty of Medicine,
Istanbul, Turkey
Received March 15, 2013; Accepted April 23, 2013; Epub May 15, 2013; Published June 1, 2013
Abstract: Primary central nervous system lymphoma (PCNSL) is defined as the involvement of brain, leptomeninges, eyes or spinal cord by
non-Hodgkin lymphoma. The role of various prognostic markers in predicting adverse outcome is debated. Objectives: To investigate the
clinical and immunohistochemical findings of immunocompetent PCNSL cases (39 cases) diagnosed at the study center, and evaluate the
influence of potential prognostic factors on overall survival (OS) of patients. Methods: Data regarding patient characteristics, neuroimaging,
pathological and immunohistochemical features and follow-up were obtained from patient records. The influence of potential prognostic
parameters on OS was investigated by log-rank test and Cox regression analysis. Results: Patients who received combined chemotherapy
and radiotherapy had a significantly better OS when compared to chemotherapy alone. Other variables included in this study were not
associated with a significant survival advantage. Conclusion: In this study, we failed to demonstrate a relationship between different
clinicopathological variables and OS of patients. Prospective studies with large patient series are needed to investigate other potential
prognostic factors. (IJCEP1303033).
Keywords: Primary central nervous system lymphoma, immunocompetent, PCNSL, prognosis, survival
Address correspondence to: Dr. Hilal Aki, Cerrahpasa Faculty of Medicine, Department of Pathology, Fatih, Istanbul, Turkey. Phone: +90 533
729 7538; Fax: +90 212 632 0050; E-mail: hilal_aki@yahoo.com.tr
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