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Int J Clin Exp Pathol 2013;6(8):1516-1522
Original Article
Inhibition of GAP-43 by propentofylline in a rat model of neuropathic pain
Feixiang Wu, Xuerong Miao, Jiaying Chen, Zhiqiang Liu, Yong Tao, Weifeng Yu, Yuming Sun
Department of Anesthesiology, Eastern Hepatobiliary Hospital, the Second Military Medical University, No. 225 Changhai Road, Shanghai
200433, China; Department of Anesthesiology, Shanghai First Maternity and Infant Hospital, Tongji University School of Medicine, No. 536
Changle Road, Shanghai 200126, China
Received June 26, 2013; Accepted July 11, 2013; Epub July 15, 2013; Published August 1, 2013
Abstract: Neural plasticity within the spinal nociceptive network may be fundamental to the chronic nature of neuropathic pain. The relation of
growth-associated protein-43 (GAP-43), a protein involved in the nerve fiber growth and sprouting, to pain hypersensitivity has been
investigated. Glial activation and inflammatory cytokines released by microglia and astrocytes are considered to be involved in the neural
sprouting and plasticity. In the present study, the anti-nociception effect of propentofylline, a glial modulating agent, was investigated in a rat
chronic constriction injury (CCI) model aiming to explore the role of GAP-43 expression. Our results demonstrated that propentofylline could
attenuate the CCI-induced mechanical allodynia and thermal hyperalgesia and inhibit the astrocyte activation and production of IL-1β. GAP-43
expression was also down-regulated by intrathecal propentofylline. These findings suggest that astrocyte activation is involved in the regulation
of GAP-43 expression and propentofylline might be used in the treatment of neuropathic pain. (IJCEP1306029).
Keywords: Astrocytes, growth-associated protein-43, interleukin 1β, neuropathic pain
Address correspondence to: Dr. Weifeng Yu, Department of Anesthesiology, Eastern Hepato-biliary Hospital, the Second Military Medical
University, No. 225 Changhai Road, Shanghai 200433, China. E-mail: ywf808@smmu.edu.cn; Dr. Yuming Sun, Department of Anesthesiology,
Eastern Hepatobiliary Hospital, the Second Military Medical University, No. 225 Changhai Road, Shanghai 200433, China. E-mail:
sunyuming2008@gmail.com
Original Article
Inhibition of GAP-43 by propentofylline in a rat model of neuropathic pain
Feixiang Wu, Xuerong Miao, Jiaying Chen, Zhiqiang Liu, Yong Tao, Weifeng Yu, Yuming Sun
Department of Anesthesiology, Eastern Hepatobiliary Hospital, the Second Military Medical University, No. 225 Changhai Road, Shanghai
200433, China; Department of Anesthesiology, Shanghai First Maternity and Infant Hospital, Tongji University School of Medicine, No. 536
Changle Road, Shanghai 200126, China
Received June 26, 2013; Accepted July 11, 2013; Epub July 15, 2013; Published August 1, 2013
Abstract: Neural plasticity within the spinal nociceptive network may be fundamental to the chronic nature of neuropathic pain. The relation of
growth-associated protein-43 (GAP-43), a protein involved in the nerve fiber growth and sprouting, to pain hypersensitivity has been
investigated. Glial activation and inflammatory cytokines released by microglia and astrocytes are considered to be involved in the neural
sprouting and plasticity. In the present study, the anti-nociception effect of propentofylline, a glial modulating agent, was investigated in a rat
chronic constriction injury (CCI) model aiming to explore the role of GAP-43 expression. Our results demonstrated that propentofylline could
attenuate the CCI-induced mechanical allodynia and thermal hyperalgesia and inhibit the astrocyte activation and production of IL-1β. GAP-43
expression was also down-regulated by intrathecal propentofylline. These findings suggest that astrocyte activation is involved in the regulation
of GAP-43 expression and propentofylline might be used in the treatment of neuropathic pain. (IJCEP1306029).
Keywords: Astrocytes, growth-associated protein-43, interleukin 1β, neuropathic pain
Address correspondence to: Dr. Weifeng Yu, Department of Anesthesiology, Eastern Hepato-biliary Hospital, the Second Military Medical
University, No. 225 Changhai Road, Shanghai 200433, China. E-mail: ywf808@smmu.edu.cn; Dr. Yuming Sun, Department of Anesthesiology,
Eastern Hepatobiliary Hospital, the Second Military Medical University, No. 225 Changhai Road, Shanghai 200433, China. E-mail:
sunyuming2008@gmail.com
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