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| IJCEP Copyright © 2007-All rights reserved. |
| International Journal of Clinical and Experimental Pathology |
Int J Clin Exp Pathol 1(1):91-97;2008
Case Report
Composite Small Lymphocytic Lymphoma and Extra-medullary Myeloid Tumor: A
Potential Diagnostic Pitfall
Shiyong Li, Karen P. Mann and Jeannine T. Holden
Department of Pathology and Laboratory Medicine, Emory University School of Medicine and Emory University Hospital, Atlanta, GA
Received 18 April 2007; accepted 28 April 2007; available online 1 January 2008
Abstract: Reported herein is a case of composite small lymphocytic lymphoma (SLL) and extramedullary myeloid tumor (EMT) occurring
in the same lymph node. Routine morphologic examination revealed a diffuse proliferation of small mature lymphocytes with numerous
irregularly dispersed nodules, closely resembling SLL with prominent proliferation centers or Richter’s transformation. Flow cytometric
immunophenotyping and immunohistochemical stains demonstrated the presence of SLL cells as well as myeloblasts, confirming the
diagnosis of a composite SLL and EMT. Conventional cytogenetics and fluorescence in situ hybridization studies revealed inversion 16
chromosome involving the core binding factor beta and myosin heavy chain 11 genes, characteristic of acute myeloid leukemia with
abnormal bone marrow eosinophils and inv(16) or t(16;16) [CBFbeta/MYH11]. In conclusion, the occurrence of SLL and EMT in the same
lymph node is rare and multiparameter approach is essential for a definitive diagnosis. (IJCEP704000).
Key Words: Extramedullary myeloid tumor, small lymphocytic lymphoma, flow cytometric immunophenotyping, immunohistochemistry,
karyotype, fluorescence in situ hybridization
Full Text: PDF .
Address all correspondences to: Shiyong Li, MD, PhD, Department of Pathology and Laboratory Medicine, Emory University Hospital,
Room F143D, 1364 Clifton Road NE, Atlanta, GA 30322, USA. Tel: 404-712-5456; Fax: 404-712-4140; Email: sli2@emory.edu.
Case Report
Composite Small Lymphocytic Lymphoma and Extra-medullary Myeloid Tumor: A
Potential Diagnostic Pitfall
Shiyong Li, Karen P. Mann and Jeannine T. Holden
Department of Pathology and Laboratory Medicine, Emory University School of Medicine and Emory University Hospital, Atlanta, GA
Received 18 April 2007; accepted 28 April 2007; available online 1 January 2008
Abstract: Reported herein is a case of composite small lymphocytic lymphoma (SLL) and extramedullary myeloid tumor (EMT) occurring
in the same lymph node. Routine morphologic examination revealed a diffuse proliferation of small mature lymphocytes with numerous
irregularly dispersed nodules, closely resembling SLL with prominent proliferation centers or Richter’s transformation. Flow cytometric
immunophenotyping and immunohistochemical stains demonstrated the presence of SLL cells as well as myeloblasts, confirming the
diagnosis of a composite SLL and EMT. Conventional cytogenetics and fluorescence in situ hybridization studies revealed inversion 16
chromosome involving the core binding factor beta and myosin heavy chain 11 genes, characteristic of acute myeloid leukemia with
abnormal bone marrow eosinophils and inv(16) or t(16;16) [CBFbeta/MYH11]. In conclusion, the occurrence of SLL and EMT in the same
lymph node is rare and multiparameter approach is essential for a definitive diagnosis. (IJCEP704000).
Key Words: Extramedullary myeloid tumor, small lymphocytic lymphoma, flow cytometric immunophenotyping, immunohistochemistry,
karyotype, fluorescence in situ hybridization
Full Text: PDF .
Address all correspondences to: Shiyong Li, MD, PhD, Department of Pathology and Laboratory Medicine, Emory University Hospital,
Room F143D, 1364 Clifton Road NE, Atlanta, GA 30322, USA. Tel: 404-712-5456; Fax: 404-712-4140; Email: sli2@emory.edu.