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| IJCEP Copyright © 2007-All rights reserved. |
| International Journal of Clinical and Experimental Pathology |
Int J Clin Exp Pathol 1(1):57-64;2008
Original Article
Expression of Claudin-7 in Benign Kidney and Kidney Tumors
Lin Li, Jorge L. Yao, P. Anthony di Sant’Agnese, Patricia A. Bourne, Maria M. Picken, Andrew N. Young, Steven S. Shen and Jiaoti Huang
Department of Pathology, University of Rochester Medical Center, Rochester, NY, USA, Department of Pathology, Loyola University
Medical Center, Maywood, IL, USA, Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA,
USA and Department of Pathology, The Methodist Hospital, Houston, TX, USA
Received 16 May 2007; accepted 4 June 2007; available online 1 January 2008
Abstract: Claudins, a family of tight junction-related transmembrane proteins, have been implicated in the pathogenesis of various
human neoplasms. Expression of claudin-7 was increased in chromophobe renal cell carcinoma in a recent oligonucleotide microarray
study. We studied the expression of claudin-7 in benign and neoplastic kidneys by immunohistochemical staining. Distal nephron (distal
convoluted tubule and thick ascending limb of Henle’s loop) epithelium showed strong membranous staining in 100% (174/174) of the
cases. Chromophobe renal cell carcinoma was positive for claudin-7 expression in 100% (36/36) of cases, while papillary renal cell
carcinoma, oncocytoma and clear cell renal cell carcinoma were positive in 90% (71/80), 45% (21/47) and 7% (7/98) of the cases,
respectively. Differential expression of Claudin-7 in different types of renal cell neoplasms can be useful in their differential diagnosis,
particularly when used in a panel of markers. In addition, results from this study support previous reports of distal nephron origin for
chromophobe renal cell carcinoma and oncocytoma. The data also suggest that, as far as claudin-7 expression is concerned, papillary
renal cell carcinoma may be more closely related to the distal nephron, rather than the proximal nephron. (IJCEP705001).
Key Words: claudin-7, kidney, neoplasm, clear cell, chromophobe, papillary, oncocytoma
Full Text: PDF
Address all correspondences to: Jiaoti Huang, MD, PhD, Department of Pathology, University of Rochester Medical Center, 601
Elmwood Ave., Box 626, Rochester, NY 14642. Tel: 585-275-8526, Fax: 585-273-3237, Email: Jiaoti_Huang@urmc.rochester.edu.
Original Article
Expression of Claudin-7 in Benign Kidney and Kidney Tumors
Lin Li, Jorge L. Yao, P. Anthony di Sant’Agnese, Patricia A. Bourne, Maria M. Picken, Andrew N. Young, Steven S. Shen and Jiaoti Huang
Department of Pathology, University of Rochester Medical Center, Rochester, NY, USA, Department of Pathology, Loyola University
Medical Center, Maywood, IL, USA, Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA,
USA and Department of Pathology, The Methodist Hospital, Houston, TX, USA
Received 16 May 2007; accepted 4 June 2007; available online 1 January 2008
Abstract: Claudins, a family of tight junction-related transmembrane proteins, have been implicated in the pathogenesis of various
human neoplasms. Expression of claudin-7 was increased in chromophobe renal cell carcinoma in a recent oligonucleotide microarray
study. We studied the expression of claudin-7 in benign and neoplastic kidneys by immunohistochemical staining. Distal nephron (distal
convoluted tubule and thick ascending limb of Henle’s loop) epithelium showed strong membranous staining in 100% (174/174) of the
cases. Chromophobe renal cell carcinoma was positive for claudin-7 expression in 100% (36/36) of cases, while papillary renal cell
carcinoma, oncocytoma and clear cell renal cell carcinoma were positive in 90% (71/80), 45% (21/47) and 7% (7/98) of the cases,
respectively. Differential expression of Claudin-7 in different types of renal cell neoplasms can be useful in their differential diagnosis,
particularly when used in a panel of markers. In addition, results from this study support previous reports of distal nephron origin for
chromophobe renal cell carcinoma and oncocytoma. The data also suggest that, as far as claudin-7 expression is concerned, papillary
renal cell carcinoma may be more closely related to the distal nephron, rather than the proximal nephron. (IJCEP705001).
Key Words: claudin-7, kidney, neoplasm, clear cell, chromophobe, papillary, oncocytoma
Full Text: PDF
Address all correspondences to: Jiaoti Huang, MD, PhD, Department of Pathology, University of Rochester Medical Center, 601
Elmwood Ave., Box 626, Rochester, NY 14642. Tel: 585-275-8526, Fax: 585-273-3237, Email: Jiaoti_Huang@urmc.rochester.edu.