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| IJCEP Copyright © 2007-All rights reserved. |
| International Journal of Clinical and Experimental Pathology |
Int J Clin Exp Pathol 1(2):117-123;2008
Review Article
IL27: Its Roles in the Induction and Inhibition of Inflammation
Joseph W. Carl Jr.and Xue-Feng Bai
Department of Pathology and Comprehensive Cancer Center, The Ohio State University Medical Center,
Columbus, OH 43210
Received 3 July 2007; accepted and available online 1 January 2008
Abstract: IL27 is the newest member of the IL6/IL12 family. It consists of Epstein-Barr virus-induced gene 3 (EBI3) and p28 subunits and
signals through the IL27 receptor complex formed by WSX-1 and gp130 subunits. IL27-IL27 receptor interaction was initially shown to
induce an early signal for the induction of Th1 responses. Recently other studies indicate that IL27 inhibits inflammatory Th17 lineage
development. Despite the overall effects observed, the role of individual IL27 subunits remains controversial and is largely unclear. EBI3,
while predominately found with p28 to form IL27, has different expression kinetics than p28. P28 has also been shown to signal
independently of EBI3. Moreover, EBI3 has other potential binding partners such as the p35 subunit of IL12 and theoretically may regulate
the inflammatory response through yet undiscovered mechanisms. Understanding the inflammatory and anti-inflammatory roles of IL27
and its subunits are essential before the immunological regulatory therapies can be developed. (IJCEP707003).
Key Words: IL27, IL6, IL12, inflammation, induction, inhibition
Full Text PDF
Address all correspondences to: Xue-Feng Bai, MD, PhD, Department of Pathology and Comprehensive Cancer Center, The Ohio State
University Medical Center, Columbus, OH 43210, Email: Xue-Feng.Bai@osumc.edu.
Review Article
IL27: Its Roles in the Induction and Inhibition of Inflammation
Joseph W. Carl Jr.and Xue-Feng Bai
Department of Pathology and Comprehensive Cancer Center, The Ohio State University Medical Center,
Columbus, OH 43210
Received 3 July 2007; accepted and available online 1 January 2008
Abstract: IL27 is the newest member of the IL6/IL12 family. It consists of Epstein-Barr virus-induced gene 3 (EBI3) and p28 subunits and
signals through the IL27 receptor complex formed by WSX-1 and gp130 subunits. IL27-IL27 receptor interaction was initially shown to
induce an early signal for the induction of Th1 responses. Recently other studies indicate that IL27 inhibits inflammatory Th17 lineage
development. Despite the overall effects observed, the role of individual IL27 subunits remains controversial and is largely unclear. EBI3,
while predominately found with p28 to form IL27, has different expression kinetics than p28. P28 has also been shown to signal
independently of EBI3. Moreover, EBI3 has other potential binding partners such as the p35 subunit of IL12 and theoretically may regulate
the inflammatory response through yet undiscovered mechanisms. Understanding the inflammatory and anti-inflammatory roles of IL27
and its subunits are essential before the immunological regulatory therapies can be developed. (IJCEP707003).
Key Words: IL27, IL6, IL12, inflammation, induction, inhibition
Full Text PDF
Address all correspondences to: Xue-Feng Bai, MD, PhD, Department of Pathology and Comprehensive Cancer Center, The Ohio State
University Medical Center, Columbus, OH 43210, Email: Xue-Feng.Bai@osumc.edu.