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Int J Clin Exp Pathol 1(2):117-123;2008

Review Article
IL27: Its Roles in the Induction and Inhibition of Inflammation

Joseph W. Carl Jr.and Xue-Feng Bai

Department of Pathology and Comprehensive Cancer Center, The Ohio State University Medical Center,
Columbus, OH 43210

Received 3 July 2007; accepted and available online 1 January 2008

Abstract: IL27 is the newest member of the IL6/IL12 family. It consists of Epstein-Barr virus-induced gene 3 (EBI3) and p28 subunits and
signals through the IL27 receptor complex formed by WSX-1 and gp130 subunits. IL27-IL27 receptor interaction was initially shown to induce
an early signal for the induction of Th1 responses. Recently other studies indicate that IL27 inhibits inflammatory Th17 lineage development.
Despite the overall effects observed, the role of individual IL27 subunits remains controversial and is largely unclear. EBI3, while
predominately found with p28 to form IL27, has different expression kinetics than p28. P28 has also been shown to signal independently of
EBI3. Moreover, EBI3 has other potential binding partners such as the p35 subunit of IL12 and theoretically may regulate the inflammatory
response through yet undiscovered mechanisms. Understanding the inflammatory and anti-inflammatory roles of IL27 and its subunits are
essential before the immunological regulatory therapies can be developed. (IJCEP707003).

Key Words: IL27, IL6, IL12, inflammation, induction, inhibition

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Address all correspondence to: Xue-Feng Bai, MD, PhD, Department of Pathology and Comprehensive Cancer Center, The Ohio State
University Medical Center, Columbus, OH 43210, Email:
Xue-Feng.Bai@osumc.edu.