 | |  | |  | |  | |  | |  | |  | |  |
| IJCEP Copyright © 2007-All rights reserved. |
| International Journal of Clinical and Experimental Pathology |
Int J Clin Exp Pathol 1(5):396-402;2008
Review Article
Fibrosing Cholestatic Hepatitis: Clinicopathologic Spectrum, Diagnosis and
Pathogenesis
Shu-Yuan Xiao, Liang Lu and Hanlin L. Wang
Departments of Pathology and of Internal Medicine, and Institute for Human Infections and Immunity, University of Texas Medical Branch,
Galveston, Texas; Department of Pathology and Laboratory Medicine, Cedars-Sinai Medical Center, Los Angeles, California
Received 2 Oct 2007; accepted and available online 1 January 2008
Abstract: Fibrosing cholestatic hepatitis (FCH) is a rapidly progressive, sometimes fatal form of liver injury. Though originally reported in
liver transplant recipients with recurrent hepatitis B, it has now been recognized frequently in chronic hepatitis B or C patients who are
under immunosuppression. The histopathologic hallmarks in the liver include marked hepatocytic injury, severe cholestasis, and
periportal and pericellular fibrosis. The pathogenesis is largely unknown. The aim of this review is to describe the spectrum of clinical
conditions in which FCH occurs, common histopathologic findings, features unique to certain underlying diseases, factors to be
considered in differential diagnosis, and our current understanding of pathogenesis of this disease. (IJCEP710002).
Key Words: Viral hepatitis, hepatitis B virus, hepatitis C virus, liver transplantation, pathogenesis
Full Text PDF
Address all correspondences to: Shu-Yuan Xiao, M.D., Departments of Pathology and of Internal Medicine, and Institute for Human
Infections and Immunity, Route 0588, University of Texas Medical Branch, 301 University Boulevard, Galveston, Texas; Email:
syxiao@utmb.edu
Review Article
Fibrosing Cholestatic Hepatitis: Clinicopathologic Spectrum, Diagnosis and
Pathogenesis
Shu-Yuan Xiao, Liang Lu and Hanlin L. Wang
Departments of Pathology and of Internal Medicine, and Institute for Human Infections and Immunity, University of Texas Medical Branch,
Galveston, Texas; Department of Pathology and Laboratory Medicine, Cedars-Sinai Medical Center, Los Angeles, California
Received 2 Oct 2007; accepted and available online 1 January 2008
Abstract: Fibrosing cholestatic hepatitis (FCH) is a rapidly progressive, sometimes fatal form of liver injury. Though originally reported in
liver transplant recipients with recurrent hepatitis B, it has now been recognized frequently in chronic hepatitis B or C patients who are
under immunosuppression. The histopathologic hallmarks in the liver include marked hepatocytic injury, severe cholestasis, and
periportal and pericellular fibrosis. The pathogenesis is largely unknown. The aim of this review is to describe the spectrum of clinical
conditions in which FCH occurs, common histopathologic findings, features unique to certain underlying diseases, factors to be
considered in differential diagnosis, and our current understanding of pathogenesis of this disease. (IJCEP710002).
Key Words: Viral hepatitis, hepatitis B virus, hepatitis C virus, liver transplantation, pathogenesis
Full Text PDF
Address all correspondences to: Shu-Yuan Xiao, M.D., Departments of Pathology and of Internal Medicine, and Institute for Human
Infections and Immunity, Route 0588, University of Texas Medical Branch, 301 University Boulevard, Galveston, Texas; Email:
syxiao@utmb.edu