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| IJCEP Copyright © 2007-All rights reserved. |
| International Journal of Clinical and Experimental Pathology |
Int J Clin Exp Pathol 1(5):387-395;2008
Review Article
Hematopoietic Disorders in Down Syndrome
John K. Choi
Division of Hematopathology and Immunohistochemistry, Children's Hospital of Philadelphia, University of Pennsylvania, Philadelphia, PA
Received December 13, 2007; accepted and available online 1 January 2008
Abstract:Patients with Down syndrome have an increased risk of developing various hematological disorders. In this article, the clinical
characteristics and differential diagnosis of the hematological disorders associated with Down syndrome are reviewed, and the
underlying molecular mechanisms discussed. (IJCEP712003).
Key Words: Down syndrome, transient myeloproliferative disorder, acute leukemia, myelodysplastic syndrome
Full Text PDF
Address all correspondences to: John Kim Choi, M.D., Ph.D., Director of Pediatric Hematopathology and Immunohistochemistry, 802F
ARC, 3615 Civic Center Blvd., Children's Hospital of Philadelphia, University of Pennsylvania, Philadelphia, PA 19104-4399. Tel:
215-590-7194; Fax: 215-590-0342; Email: choijo@email.chop.edu or johnkimchoi1@gmail.com
Review Article
Hematopoietic Disorders in Down Syndrome
John K. Choi
Division of Hematopathology and Immunohistochemistry, Children's Hospital of Philadelphia, University of Pennsylvania, Philadelphia, PA
Received December 13, 2007; accepted and available online 1 January 2008
Abstract:Patients with Down syndrome have an increased risk of developing various hematological disorders. In this article, the clinical
characteristics and differential diagnosis of the hematological disorders associated with Down syndrome are reviewed, and the
underlying molecular mechanisms discussed. (IJCEP712003).
Key Words: Down syndrome, transient myeloproliferative disorder, acute leukemia, myelodysplastic syndrome
Full Text PDF
Address all correspondences to: John Kim Choi, M.D., Ph.D., Director of Pediatric Hematopathology and Immunohistochemistry, 802F
ARC, 3615 Civic Center Blvd., Children's Hospital of Philadelphia, University of Pennsylvania, Philadelphia, PA 19104-4399. Tel:
215-590-7194; Fax: 215-590-0342; Email: choijo@email.chop.edu or johnkimchoi1@gmail.com