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| IJCEP Copyright © 2007-All rights reserved. |
| International Journal of Clinical and Experimental Pathology |
Int J Clin Exp Pathol 2(2), 119-131;2009
Review Article
A Practical and Comprehensive Immunohistochemical Approach to the Diagnosis of
Superficial Soft Tissue Tumors
Wael Al-Daraji, Ehab Husain, Bettena G Zelger and Bernhard Zelger
Departments of Pathology1 and Surgery2, Pennsylvania State University Hershey Medical Center, Hershey, PA, USA and 3Department of
Pathology, The University of Texas M. D. Anderson Cancer Center, Houston, TX, USA
Received 13 March 2008; Accepted in revision 23 April 2008; Available online 10 June 2008
Abstract: Soft tissue tumors include neoplasms of specific and unknown lineages, and, therefore, lineage markers of smooth muscle,
skeletal muscle, endothelial, epithelial and Schwann cells have proven useful in everyday practice. However, groups of tumors remain
that are defined essentially on grounds of histology; others can be defined by molecular genetic studies. The complex distribution
patterns of many antigens and loss of some differentiation antigens in malignant tumors often necessitate the use of panels of
antibodies. Optimally such panels should address all significant differential diagnostic alternatives. There is little doubt that numerous
new differentiation markers will appear in the future. The evaluation of tumor proliferation, apoptosis, and cell cycle control will give new
information related to tumor biology and prognosis. (IJCEP803010).
Key Words: Soft tissue tumors, skin, immunohistochemistry
Full text PDF
Address all correspondences to: Dr Wael Al-Daraji, School of Molecular Medical Sciences, Division of Pathology, Queen’s medical
Centre, Nottingham, NG7 2UH, UK. Email: waldaraji@aol.com
Review Article
A Practical and Comprehensive Immunohistochemical Approach to the Diagnosis of
Superficial Soft Tissue Tumors
Wael Al-Daraji, Ehab Husain, Bettena G Zelger and Bernhard Zelger
Departments of Pathology1 and Surgery2, Pennsylvania State University Hershey Medical Center, Hershey, PA, USA and 3Department of
Pathology, The University of Texas M. D. Anderson Cancer Center, Houston, TX, USA
Received 13 March 2008; Accepted in revision 23 April 2008; Available online 10 June 2008
Abstract: Soft tissue tumors include neoplasms of specific and unknown lineages, and, therefore, lineage markers of smooth muscle,
skeletal muscle, endothelial, epithelial and Schwann cells have proven useful in everyday practice. However, groups of tumors remain
that are defined essentially on grounds of histology; others can be defined by molecular genetic studies. The complex distribution
patterns of many antigens and loss of some differentiation antigens in malignant tumors often necessitate the use of panels of
antibodies. Optimally such panels should address all significant differential diagnostic alternatives. There is little doubt that numerous
new differentiation markers will appear in the future. The evaluation of tumor proliferation, apoptosis, and cell cycle control will give new
information related to tumor biology and prognosis. (IJCEP803010).
Key Words: Soft tissue tumors, skin, immunohistochemistry
Full text PDF
Address all correspondences to: Dr Wael Al-Daraji, School of Molecular Medical Sciences, Division of Pathology, Queen’s medical
Centre, Nottingham, NG7 2UH, UK. Email: waldaraji@aol.com