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| IJCEP Copyright © 2007-All rights reserved. |
| International Journal of Clinical and Experimental Pathology |
Int J Clin Exp Pathol 1(6), 461-474; 2008
Review Article
HOX Proteins and Leukemia
Kajal V. Sitwala, Monisha N. Dandekar and Jay L. Hess
Department of Pathology, The University of Michigan Medical School, Ann Arbor, Michigan, 48109, USA
Received March 24, 2008; accepted and available online March 30, 2008
Abstract: HOX and three amino acid loop extension (TALE) proteins cooperate to induce transformation in mouse leukemia models, and
are dysregulated in a variety of human leukemias. Despite decades of research, the mechanism of action for HOX proteins in
embryogenesis and hematopoiesis remains unclear. Recent studies on the roles of Hoxa9 and Meis1 in leukemia has led to a wealth of
new data, but their molecular mechanisms of action and synergy remain obscure. Advances in genome-wide technologies offer new
avenues for understanding how homeodomain-containing transcription factors exert their programs in normal and neoplastic
development. (IJCEP803015).
Key Words: HOX, leukemia
Full text PDF
Address all correspondences to: Jay L. Hess M.D., Ph.D, M5240 Medical Sciences I, 1301 Catherine Street, Ann Arbor, MI 48109-0602,
Phone: (734) 763-6384, Fax: (734) 763-4782, Email: jayhess@umich.edu
Review Article
HOX Proteins and Leukemia
Kajal V. Sitwala, Monisha N. Dandekar and Jay L. Hess
Department of Pathology, The University of Michigan Medical School, Ann Arbor, Michigan, 48109, USA
Received March 24, 2008; accepted and available online March 30, 2008
Abstract: HOX and three amino acid loop extension (TALE) proteins cooperate to induce transformation in mouse leukemia models, and
are dysregulated in a variety of human leukemias. Despite decades of research, the mechanism of action for HOX proteins in
embryogenesis and hematopoiesis remains unclear. Recent studies on the roles of Hoxa9 and Meis1 in leukemia has led to a wealth of
new data, but their molecular mechanisms of action and synergy remain obscure. Advances in genome-wide technologies offer new
avenues for understanding how homeodomain-containing transcription factors exert their programs in normal and neoplastic
development. (IJCEP803015).
Key Words: HOX, leukemia
Full text PDF
Address all correspondences to: Jay L. Hess M.D., Ph.D, M5240 Medical Sciences I, 1301 Catherine Street, Ann Arbor, MI 48109-0602,
Phone: (734) 763-6384, Fax: (734) 763-4782, Email: jayhess@umich.edu