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Int J Clin Exp Pathol 2(1),104-107;2009
Case Report
Metastatic Prostatic Carcinoma to Testis: Histological Features Mimicking Lymphoma
Bisong Haupt, Jae Y. Ro, Alberto G. Ayala and Jim Zhai
Department of Pathology, The Methodist Hospital, Weill College of Medicine of Cornell University, 6565 Fannin Street, Houston, TX
Received 30 April 2008; Accepted and available online 10 May 2008
Abstract: We report a case of prostatic carcinoma with testicular metastasis, which mimicked malignant lymphoma of the testis. The patient
was a 71 year-old man with a history of prostate adenocarcinoma of Gleason score 9 (4+5) diagnosed in 2001 for which he received hormonal
therapy. Four years later, the patient developed multiple osteoblastic bone metastases. Radiotherapy of the bone metastases was given with
subsequently bilateral orchiectomy for hormonal deprivation therapy in May 2005. Grossly, one of the testes had a subcapsular rubbery 0.9 cm
nodule. Microscopically, the nodule was composed of malignant discohesive cells predominantly infiltrating in the interstitium with an
appearance of malignant lymphoma. However, immunohistochemical stains were positive for prostate-specific antigen and prostate acid
phosphatase and negative for leukocyte common antigen, which confirmed the diagnosis of metastatic prostate adenocarcinoma.
(IJCEP804004).
Key Words: prostate cancer, metastasis, testis, lymphoma
Full text PDF
Address all correspondence to: Jim Zhai, MD, Department of Pathology, The Methodist Hospital, Weill College of Medicine of Cornell
University, 6565 Fannin Street, Houston TX 77030. Tel: 713-441-6409; Fax: 713-793-1603; Email: qzhai@tmhs.org
Case Report
Metastatic Prostatic Carcinoma to Testis: Histological Features Mimicking Lymphoma
Bisong Haupt, Jae Y. Ro, Alberto G. Ayala and Jim Zhai
Department of Pathology, The Methodist Hospital, Weill College of Medicine of Cornell University, 6565 Fannin Street, Houston, TX
Received 30 April 2008; Accepted and available online 10 May 2008
Abstract: We report a case of prostatic carcinoma with testicular metastasis, which mimicked malignant lymphoma of the testis. The patient
was a 71 year-old man with a history of prostate adenocarcinoma of Gleason score 9 (4+5) diagnosed in 2001 for which he received hormonal
therapy. Four years later, the patient developed multiple osteoblastic bone metastases. Radiotherapy of the bone metastases was given with
subsequently bilateral orchiectomy for hormonal deprivation therapy in May 2005. Grossly, one of the testes had a subcapsular rubbery 0.9 cm
nodule. Microscopically, the nodule was composed of malignant discohesive cells predominantly infiltrating in the interstitium with an
appearance of malignant lymphoma. However, immunohistochemical stains were positive for prostate-specific antigen and prostate acid
phosphatase and negative for leukocyte common antigen, which confirmed the diagnosis of metastatic prostate adenocarcinoma.
(IJCEP804004).
Key Words: prostate cancer, metastasis, testis, lymphoma
Full text PDF
Address all correspondence to: Jim Zhai, MD, Department of Pathology, The Methodist Hospital, Weill College of Medicine of Cornell
University, 6565 Fannin Street, Houston TX 77030. Tel: 713-441-6409; Fax: 713-793-1603; Email: qzhai@tmhs.org
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