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| IJCEP Copyright © 2007-All rights reserved. |
| International Journal of Clinical and Experimental Pathology |
Int J Clin Exp Pathol 2(1),104-107;2009
Case Report
Metastatic Prostatic Carcinoma to Testis: Histological Features Mimicking Lymphoma
Bisong Haupt, Jae Y. Ro, Alberto G. Ayala and Jim Zhai
Department of Pathology, The Methodist Hospital, Weill College of Medicine of Cornell University, 6565 Fannin Street, Houston, TX
Received 30 April 2008; Accepted and available online 10 May 2008
Abstract: We report a case of prostatic carcinoma with testicular metastasis, which mimicked malignant lymphoma of the testis. The
patient was a 71 year-old man with a history of prostate adenocarcinoma of Gleason score 9 (4+5) diagnosed in 2001 for which he
received hormonal therapy. Four years later, the patient developed multiple osteoblastic bone metastases. Radiotherapy of the bone
metastases was given with subsequently bilateral orchiectomy for hormonal deprivation therapy in May 2005. Grossly, one of the testes
had a subcapsular rubbery 0.9 cm nodule. Microscopically, the nodule was composed of malignant discohesive cells predominantly
infiltrating in the interstitium with an appearance of malignant lymphoma. However, immunohistochemical stains were positive for
prostate-specific antigen and prostate acid phosphatase and negative for leukocyte common antigen, which confirmed the diagnosis of
metastatic prostate adenocarcinoma. (IJCEP804004).
Key Words: prostate cancer, metastasis, testis, lymphoma
Full text PDF
Address all correspondences to: Jim Zhai, MD, Department of Pathology, The Methodist Hospital, Weill College of Medicine of Cornell
University, 6565 Fannin Street, Houston TX 77030. Tel: 713-441-6409; Fax: 713-793-1603; Email: qzhai@tmhs.org
Case Report
Metastatic Prostatic Carcinoma to Testis: Histological Features Mimicking Lymphoma
Bisong Haupt, Jae Y. Ro, Alberto G. Ayala and Jim Zhai
Department of Pathology, The Methodist Hospital, Weill College of Medicine of Cornell University, 6565 Fannin Street, Houston, TX
Received 30 April 2008; Accepted and available online 10 May 2008
Abstract: We report a case of prostatic carcinoma with testicular metastasis, which mimicked malignant lymphoma of the testis. The
patient was a 71 year-old man with a history of prostate adenocarcinoma of Gleason score 9 (4+5) diagnosed in 2001 for which he
received hormonal therapy. Four years later, the patient developed multiple osteoblastic bone metastases. Radiotherapy of the bone
metastases was given with subsequently bilateral orchiectomy for hormonal deprivation therapy in May 2005. Grossly, one of the testes
had a subcapsular rubbery 0.9 cm nodule. Microscopically, the nodule was composed of malignant discohesive cells predominantly
infiltrating in the interstitium with an appearance of malignant lymphoma. However, immunohistochemical stains were positive for
prostate-specific antigen and prostate acid phosphatase and negative for leukocyte common antigen, which confirmed the diagnosis of
metastatic prostate adenocarcinoma. (IJCEP804004).
Key Words: prostate cancer, metastasis, testis, lymphoma
Full text PDF
Address all correspondences to: Jim Zhai, MD, Department of Pathology, The Methodist Hospital, Weill College of Medicine of Cornell
University, 6565 Fannin Street, Houston TX 77030. Tel: 713-441-6409; Fax: 713-793-1603; Email: qzhai@tmhs.org