 | |  | |  | |  | |  | |  | |  | |  |
| IJCEP Copyright © 2007-All rights reserved. |
| International Journal of Clinical and Experimental Pathology |
Int J Clin Exp Pathol 2(1), 71-82; 2009
Review Article
Hypothesis: Hemolytic Transfusion Reactions Represent an Alternative Type of
Anaphylaxis
Eldad A. Hod, Set A. Sokol, James C. Zimring and Steven L. Spitalnik
Department of Pathology and Cell Biology, Columbia University Medical Center, New York, NY 10032; Center for Transfusion and Cellular
Therapies, Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA 30322
Received 15 May 2008; Accepted available online 30 May 2008
Abstract: Classical anaphylaxis is the most severe, and potentially fatal, type of allergic reaction, manifested by hypotension,
bronchoconstriction, and vascular permeability. Similarly, a hemolytic transfusion reaction (HTR) is the most feared consequence of
blood transfusion. Evidence for the existence of an alternative, IgG-mediated, pathway of anaphylaxis may be relevant for explaining the
pathophysiology of IgG-HTRs. The purpose of this review is to summarize the evidence for this alternative pathway of anaphylaxis and to
present the hypothesis that an IgG-mediated HTR is one example of this type of anaphylaxis. (IJCEP805002).
Key Words: Hemolytic Transfusion Reaction, anaphylaxis, platelet Activating Factor
Full text PDF
Address all correspondences to: Steven L. Spitalnik, MD, Columbia University Medical Center, Department of Pathology and Cell Biology,
630 West 168th Street, Room P&S 15-408, New York, NY 10032, Telephone: 212-305-2204, Fax: 212-305-3693, Email:
ss2479@columbia.edu
Review Article
Hypothesis: Hemolytic Transfusion Reactions Represent an Alternative Type of
Anaphylaxis
Eldad A. Hod, Set A. Sokol, James C. Zimring and Steven L. Spitalnik
Department of Pathology and Cell Biology, Columbia University Medical Center, New York, NY 10032; Center for Transfusion and Cellular
Therapies, Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA 30322
Received 15 May 2008; Accepted available online 30 May 2008
Abstract: Classical anaphylaxis is the most severe, and potentially fatal, type of allergic reaction, manifested by hypotension,
bronchoconstriction, and vascular permeability. Similarly, a hemolytic transfusion reaction (HTR) is the most feared consequence of
blood transfusion. Evidence for the existence of an alternative, IgG-mediated, pathway of anaphylaxis may be relevant for explaining the
pathophysiology of IgG-HTRs. The purpose of this review is to summarize the evidence for this alternative pathway of anaphylaxis and to
present the hypothesis that an IgG-mediated HTR is one example of this type of anaphylaxis. (IJCEP805002).
Key Words: Hemolytic Transfusion Reaction, anaphylaxis, platelet Activating Factor
Full text PDF
Address all correspondences to: Steven L. Spitalnik, MD, Columbia University Medical Center, Department of Pathology and Cell Biology,
630 West 168th Street, Room P&S 15-408, New York, NY 10032, Telephone: 212-305-2204, Fax: 212-305-3693, Email:
ss2479@columbia.edu