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| IJCEP Copyright © 2007-All rights reserved. |
| International Journal of Clinical and Experimental Pathology |
Int J Clin Exp Pathol 2(2),163-168;2009
Original Article
Pharmacogenetic Contribution of Leptin Gene Polymorphism in Cutaneous T-Cell
Lymphoma
Vladimir Vasku, Anna Vasku and Julie Bienertova Vasku
First Department of Dermatology, St. Ann’s Faculty Hospital and Department of Pathophysiology, Faculty of Medicine, Masaryk University,
Brno, Czech Republic
Received 11 June 2008; Accepted in revision 3 July 2008; Available online 18 July 2008
Abstract: Leptin has recently attracted more attention due to its specific effects in the pathogenesis of malignancies. The aim of this study
was to investigate the possible association between variants of -2548 G/A polymorphism in leptin (LEP) gene and cutaneous T-cell
lymphomas (CTCL), with respect to the treatment responsiveness. A sample of 91 patients with CTCL was compared to 198 control
individuals. The CTCL men with AG and/or GG genotype were more likely to receive the topical steroids treatment (odds ratio 7.88, 95%
confidential interval 1.51-41.04) when compared to AA patients. Our data supports the possible involvement of LEP-2548G/A
polymorphism in CTCL treatment responsiveness and thus might provide important information for individual therapy tailoring.
(IJCEP806005 ).
Key Words: Leptin, gene polymorphism, pharmacogenetics, cutaneous T-cell lymphoma
Full text PDF
Address all correspondences to: Professor Anna Vasku, MD., CSc., Department of Pathophysiology, Faculty of Medicine, Masaryk
University, Komenského nám. 2, 66243 Brno, Czech Republic. Tel: +420549498262; Fax: +420549494340; Email: avasku@med.muni.cz
Original Article
Pharmacogenetic Contribution of Leptin Gene Polymorphism in Cutaneous T-Cell
Lymphoma
Vladimir Vasku, Anna Vasku and Julie Bienertova Vasku
First Department of Dermatology, St. Ann’s Faculty Hospital and Department of Pathophysiology, Faculty of Medicine, Masaryk University,
Brno, Czech Republic
Received 11 June 2008; Accepted in revision 3 July 2008; Available online 18 July 2008
Abstract: Leptin has recently attracted more attention due to its specific effects in the pathogenesis of malignancies. The aim of this study
was to investigate the possible association between variants of -2548 G/A polymorphism in leptin (LEP) gene and cutaneous T-cell
lymphomas (CTCL), with respect to the treatment responsiveness. A sample of 91 patients with CTCL was compared to 198 control
individuals. The CTCL men with AG and/or GG genotype were more likely to receive the topical steroids treatment (odds ratio 7.88, 95%
confidential interval 1.51-41.04) when compared to AA patients. Our data supports the possible involvement of LEP-2548G/A
polymorphism in CTCL treatment responsiveness and thus might provide important information for individual therapy tailoring.
(IJCEP806005 ).
Key Words: Leptin, gene polymorphism, pharmacogenetics, cutaneous T-cell lymphoma
Full text PDF
Address all correspondences to: Professor Anna Vasku, MD., CSc., Department of Pathophysiology, Faculty of Medicine, Masaryk
University, Komenského nám. 2, 66243 Brno, Czech Republic. Tel: +420549498262; Fax: +420549494340; Email: avasku@med.muni.cz