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Int J Clin Exp Pathol 2010;3(4):448-457
Case Report
Systemic mastocytosis in association with chronic lymphocytic leukemia and plasma
cell myeloma
Shouying Du, Hooman H. Rashidi, Thomas J. Kipps, H. Elizabeth. Broome, Huan-You Wang
Department of Pathology, University of California San Diego Moores Cancer Center, 3855 Health Sciences Drive, La Jolla, CA 92093-0987;
Department of Pathology, Veteran Affairs Medical Center, 3350 La Jolla Village Drive #113, La Jolla, CA 92161-113; Division of Hematology,
Department of Medicine, University of California San Diego Moores Cancer Center, La Jolla, CA 92093.
Received April 6, 2010, accepted April, 2010, available April, 2010
Abstract: Systemic mastocytosis with associated clonal haematological non-mast cell lineage disease (SM-AHNMD) is a heterogeous group
of mast cell disorders with different clinical, pathologic and underlying molecular characteristics. While myelomonocytic/myeloid neoplasia
overwhelmingly predominant the AHNMD component, lymphoproliferative disorders rarely occur as an AHNMD component of
SM-AHNMD. Here we report two cases of SM-AHNMD, in which the AHNMD component is chronic lymphocytic leukemia in one case, and
concurrent chronic lymphocytic leukemia as well as plasma cell myeloma in another case. To the best of our knowledge, this is the first case
report of SM-AHNMD with chronic lymphocytic leukemia and plasma cell dyscrasia simultaneously. (IJCEP1004001).
Key words: Chronic lymphocytic leukemia, systemic mastocytosis, systemic mastocytosis with associated clonal haematological non-mast
cell lineage disease
Full text PDF
Address all correspondence to:
Huan-You Wang, MD PhD,
Department of Pathology
UCSD Moores Cancer Center
3855 Health Sciences Drive
La Jolla, CA 92093-0987
Tel: 858-822-2538; Fax: 858-822-1415
E-mail: hywang2@ucsd.edu
Case Report
Systemic mastocytosis in association with chronic lymphocytic leukemia and plasma
cell myeloma
Shouying Du, Hooman H. Rashidi, Thomas J. Kipps, H. Elizabeth. Broome, Huan-You Wang
Department of Pathology, University of California San Diego Moores Cancer Center, 3855 Health Sciences Drive, La Jolla, CA 92093-0987;
Department of Pathology, Veteran Affairs Medical Center, 3350 La Jolla Village Drive #113, La Jolla, CA 92161-113; Division of Hematology,
Department of Medicine, University of California San Diego Moores Cancer Center, La Jolla, CA 92093.
Received April 6, 2010, accepted April, 2010, available April, 2010
Abstract: Systemic mastocytosis with associated clonal haematological non-mast cell lineage disease (SM-AHNMD) is a heterogeous group
of mast cell disorders with different clinical, pathologic and underlying molecular characteristics. While myelomonocytic/myeloid neoplasia
overwhelmingly predominant the AHNMD component, lymphoproliferative disorders rarely occur as an AHNMD component of
SM-AHNMD. Here we report two cases of SM-AHNMD, in which the AHNMD component is chronic lymphocytic leukemia in one case, and
concurrent chronic lymphocytic leukemia as well as plasma cell myeloma in another case. To the best of our knowledge, this is the first case
report of SM-AHNMD with chronic lymphocytic leukemia and plasma cell dyscrasia simultaneously. (IJCEP1004001).
Key words: Chronic lymphocytic leukemia, systemic mastocytosis, systemic mastocytosis with associated clonal haematological non-mast
cell lineage disease
Full text PDF
Address all correspondence to:
Huan-You Wang, MD PhD,
Department of Pathology
UCSD Moores Cancer Center
3855 Health Sciences Drive
La Jolla, CA 92093-0987
Tel: 858-822-2538; Fax: 858-822-1415
E-mail: hywang2@ucsd.edu
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