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Int J Clin Exp Pathol 2010;3(8):798-807
Case Report
CD20dim-positive T-cell large granular lymphocytic leukemia in a patient with concurrent
hairy cell leukemia and plasma cell myeloma
Xiangdong Xu, Elizabeth H. Broome, Hooman H. Rashidi, Sarah T. South, Marie L. Dell’Aquila, Huan-You Wang
Division of Clinical Pathology, Department of Pathology, University of California San Diego Health Sciences, 3855 Health Science Drive, La
Jolla, California 92093-0987; Department of Pathology, Veterans Affairs Medical Center, 3550 La Jolla Village Drive, San Diego, California
92161-113; Departments of Pediatrics and Pathology, ARUP Laboratories, University of Utah, Salt Lake City, UT 84108.
Received August 17, 2010; accepted August 25, 2010; available online September 12, 2010
Abstract: We report a CD20dim- positive T-cell large granular lymphocytic (T-LGL) leukemia in a patient with concurrent hairy cell leukemia and
plasma cell myeloma. This patient was first diagnosed with T-LGL leukemia with dim CD20 expression, which by itself was a rare entity. He
received no treatment for T-LGL leukemia. The patient later developed a hairy cell leukemia, which went into complete clinical remission after
one cycle of 2-CdA. Five years later, he was diagnosed with a third malignancy, plasma cell myeloma. Complex cytogenetic aberrancies were
present at the time when plasma cell myeloma was diagnosed. This is the first report, to the best of our knowledge, in the English literature
with the aforementioned three distinct hematopoietic malignancies in one patient. (IJCEP1008005).
Keywords: CD20dim-positive T-LGL leukemia with concurrent hairy cell leukemia and plasma cell myeloma
Full text PDF
Address all correspondence to:
Huan-You Wang, MD
Department of Pathology
University of California San Diego Health Sciences
3855 Health Sciences Drive
La Jolla, CA 92093-0987
Tel: (858) 822-2538; Fax: (858) 822-1415
E-mail: hywang2@ucsd.edu
Case Report
CD20dim-positive T-cell large granular lymphocytic leukemia in a patient with concurrent
hairy cell leukemia and plasma cell myeloma
Xiangdong Xu, Elizabeth H. Broome, Hooman H. Rashidi, Sarah T. South, Marie L. Dell’Aquila, Huan-You Wang
Division of Clinical Pathology, Department of Pathology, University of California San Diego Health Sciences, 3855 Health Science Drive, La
Jolla, California 92093-0987; Department of Pathology, Veterans Affairs Medical Center, 3550 La Jolla Village Drive, San Diego, California
92161-113; Departments of Pediatrics and Pathology, ARUP Laboratories, University of Utah, Salt Lake City, UT 84108.
Received August 17, 2010; accepted August 25, 2010; available online September 12, 2010
Abstract: We report a CD20dim- positive T-cell large granular lymphocytic (T-LGL) leukemia in a patient with concurrent hairy cell leukemia and
plasma cell myeloma. This patient was first diagnosed with T-LGL leukemia with dim CD20 expression, which by itself was a rare entity. He
received no treatment for T-LGL leukemia. The patient later developed a hairy cell leukemia, which went into complete clinical remission after
one cycle of 2-CdA. Five years later, he was diagnosed with a third malignancy, plasma cell myeloma. Complex cytogenetic aberrancies were
present at the time when plasma cell myeloma was diagnosed. This is the first report, to the best of our knowledge, in the English literature
with the aforementioned three distinct hematopoietic malignancies in one patient. (IJCEP1008005).
Keywords: CD20dim-positive T-LGL leukemia with concurrent hairy cell leukemia and plasma cell myeloma
Full text PDF
Address all correspondence to:
Huan-You Wang, MD
Department of Pathology
University of California San Diego Health Sciences
3855 Health Sciences Drive
La Jolla, CA 92093-0987
Tel: (858) 822-2538; Fax: (858) 822-1415
E-mail: hywang2@ucsd.edu
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