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Int J Clin Exp Pathol 2010;3(8):815-821
Case Report
Large B-cell lymphoma with an unusual infiltrating pattern: report of two cases
Neil G. Haycocks, X. Frank Zhao
Department of Pathology, University of Maryland Medical Center, Baltimore, MD, USA
Received September 15, 2010; accepted October 9, 2010; available online October 11, 2010
Abstract: Large B-cell lymphoma presents with the most varied infiltrating patterns and morphologies. Here we report two cases of unusual
large B-cell lymphoma in two old female patients. Both lymphomas show: 1) scattered and clustered large B-cells infiltrating the periphery of
polyclonal lymphoid nodules; 2) large B-cells with an immunoblastic morphology; 3) large B-cell infiltration associated with vascular
proliferation; 4) coexisting lymphoid nodules with hyaline vascular proliferation. The first case took an aggressive clinical course with
transformation into acute leukemia, and imparted a short patient survival, whereas the second case responded to chemotherapy, experienced
a local recurrence and long survival for >7 years. To our knowledge, these are the first reported cases of large B-cell lymphomas with a
paranodular infiltrating pattern, immunoblastic morphology, and associated vascular proliferation.. (IJCEP1009005).
Keywords: Paranodular, DLBCL, immunoblastic, angioproliferative
Full text PDF
Address all correspondence to:
X. Frank Zhao, MD, PhD
Department of Pathology
22 S. Greene Street, NBW54
Baltimore, MD 21201
USA.
Tel: 410-328-5555
Fax: 410-328-5508
Email: xzhao@umm.edu
Case Report
Large B-cell lymphoma with an unusual infiltrating pattern: report of two cases
Neil G. Haycocks, X. Frank Zhao
Department of Pathology, University of Maryland Medical Center, Baltimore, MD, USA
Received September 15, 2010; accepted October 9, 2010; available online October 11, 2010
Abstract: Large B-cell lymphoma presents with the most varied infiltrating patterns and morphologies. Here we report two cases of unusual
large B-cell lymphoma in two old female patients. Both lymphomas show: 1) scattered and clustered large B-cells infiltrating the periphery of
polyclonal lymphoid nodules; 2) large B-cells with an immunoblastic morphology; 3) large B-cell infiltration associated with vascular
proliferation; 4) coexisting lymphoid nodules with hyaline vascular proliferation. The first case took an aggressive clinical course with
transformation into acute leukemia, and imparted a short patient survival, whereas the second case responded to chemotherapy, experienced
a local recurrence and long survival for >7 years. To our knowledge, these are the first reported cases of large B-cell lymphomas with a
paranodular infiltrating pattern, immunoblastic morphology, and associated vascular proliferation.. (IJCEP1009005).
Keywords: Paranodular, DLBCL, immunoblastic, angioproliferative
Full text PDF
Address all correspondence to:
X. Frank Zhao, MD, PhD
Department of Pathology
22 S. Greene Street, NBW54
Baltimore, MD 21201
USA.
Tel: 410-328-5555
Fax: 410-328-5508
Email: xzhao@umm.edu
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