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Int J Clin Exp Pathol 2011;4(6):552-565
Original Article
IL-17 expression by macrophages is associated with proliferative inflammatory atrophy
lesions in prostate cancer patients
Eugene V. Vykhovanets, Gregory T. MacLennan, Olena V. Vykhovanets, Sanjay Gupta
Department of Urology and Department of Pathology, Case Western Reserve University, University Hospitals Case Medical Center, Case
Comprehensive Cancer Center, Cleveland, Ohio-44106, USA.
Received July 20, 2011; accepted July 31, 2011; Epub August 3, 2011; published August 15, 2011
Abstract: Intraprostatic leukocyte function may vary depending on local inflammatory or malignant cell microenvironment. Interleukin (IL)-17
producing cells play key roles in chronic inflammation and autoimmunity. Little is known about the relevance of IL-17 producing cells at sites of
prostate tissue inflammation and/or prostate adenocarcinoma. In this study, we analyzed thirty formalin-fixed paraffin-embedded whole-mount
radical prostatectomy specimens of prostate cancer patients. Immunohistochemistry was employed to identify IL-17 producing cells in all sites
of mononuclear cell accumulation, noting their relationships to areas of prostate cancer, proliferative inflammatory atrophy (PIA), or hyperplastic
benign tissue. Levels of IL-17 producing cells were similar in zones of benign prostate tissue and areas of prostate cancer. Pronounced
intraluminal and peri-glandular IL-17 producing cell accumulations were identified in the mononuclear cell infiltrates associated with PIA
lesions. Glandular and peri-glandular CD68+ macrophages and neutrophils were the predominant IL-17 producing cells in PIA lesions. The
accumulation of IL-17 expressing cells in PIA lesions presents direct evidence of an inflammatory microenvironment that may support the
development of prostate cancer. (IJCEP1107003).
Keywords: Chronic inflammation, IL-17, proliferative inflammatory atrophy, prostate cancer, macrophages, neutrophils, mononuclear cells
Full text PDF
Address all correspondence to:
Sanjay Gupta, PhD
Department of Urology
Case Western Reserve University
10900 Euclid Avenue Cleveland, Ohio-44106, USA.
Tel: (216) 368-6162
Fax: (216) 368-0213
E-mail: sanjay.gupta@case.edu
Original Article
IL-17 expression by macrophages is associated with proliferative inflammatory atrophy
lesions in prostate cancer patients
Eugene V. Vykhovanets, Gregory T. MacLennan, Olena V. Vykhovanets, Sanjay Gupta
Department of Urology and Department of Pathology, Case Western Reserve University, University Hospitals Case Medical Center, Case
Comprehensive Cancer Center, Cleveland, Ohio-44106, USA.
Received July 20, 2011; accepted July 31, 2011; Epub August 3, 2011; published August 15, 2011
Abstract: Intraprostatic leukocyte function may vary depending on local inflammatory or malignant cell microenvironment. Interleukin (IL)-17
producing cells play key roles in chronic inflammation and autoimmunity. Little is known about the relevance of IL-17 producing cells at sites of
prostate tissue inflammation and/or prostate adenocarcinoma. In this study, we analyzed thirty formalin-fixed paraffin-embedded whole-mount
radical prostatectomy specimens of prostate cancer patients. Immunohistochemistry was employed to identify IL-17 producing cells in all sites
of mononuclear cell accumulation, noting their relationships to areas of prostate cancer, proliferative inflammatory atrophy (PIA), or hyperplastic
benign tissue. Levels of IL-17 producing cells were similar in zones of benign prostate tissue and areas of prostate cancer. Pronounced
intraluminal and peri-glandular IL-17 producing cell accumulations were identified in the mononuclear cell infiltrates associated with PIA
lesions. Glandular and peri-glandular CD68+ macrophages and neutrophils were the predominant IL-17 producing cells in PIA lesions. The
accumulation of IL-17 expressing cells in PIA lesions presents direct evidence of an inflammatory microenvironment that may support the
development of prostate cancer. (IJCEP1107003).
Keywords: Chronic inflammation, IL-17, proliferative inflammatory atrophy, prostate cancer, macrophages, neutrophils, mononuclear cells
Full text PDF
Address all correspondence to:
Sanjay Gupta, PhD
Department of Urology
Case Western Reserve University
10900 Euclid Avenue Cleveland, Ohio-44106, USA.
Tel: (216) 368-6162
Fax: (216) 368-0213
E-mail: sanjay.gupta@case.edu
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