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Int J Clin Exp Pathol 2012;5(4):377-381
Case Report
Hemophagocytic syndrome secondary to adult-onset still’s disease but very similar to
lymphoma
Xin-Hua Zhang, Yong-Mei Han, Wen-Wen Wang, Hao Cheng, Ke-Jian Zhu
Department of Dermatology and Rheumatology, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, China
Received March 20, 2012; accepted April 7, 2012; Epub April 16, 2012; Published April 30, 2012
Abstract: Hemophagocytic syndrome (HPS) is a clinicopathologic entity characterized by increased proliferation and activation of benign
macrophages with hemophagocytosis throughout the reticuloendothelial system. HPS may be primary, or secondary to malignancy, infections,
auto-immune diseases and pharmacotherapy. In patients with adult-onset Still’s disease (AOSD), HPS is a rare but life-threatening
complication. Herein, we described a female patient with HPS secondary to AOSD. During the therapy, giant gastric ulcer similar to lymphoma
developed after treatment with corticosteroid and nonsteroidal anti-inflammatory drugs. (IJCEP1203011).
Keywords: Adult-onset Still’s disease, hemophagocytic syndrome, giant gastric ulcer
Address all correspondence to:
Dr. Yong-Mei Han
Department of Dermatology and Rheumatology
Sir Run Run Shaw Hospital
School of Medicine, Zhejiang University
Hangzhou, China.
Tel: +86571-86002113
E-mail: hanye7899@sohu.com; E-mail: 20918097@zju.edu.cn
Case Report
Hemophagocytic syndrome secondary to adult-onset still’s disease but very similar to
lymphoma
Xin-Hua Zhang, Yong-Mei Han, Wen-Wen Wang, Hao Cheng, Ke-Jian Zhu
Department of Dermatology and Rheumatology, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, China
Received March 20, 2012; accepted April 7, 2012; Epub April 16, 2012; Published April 30, 2012
Abstract: Hemophagocytic syndrome (HPS) is a clinicopathologic entity characterized by increased proliferation and activation of benign
macrophages with hemophagocytosis throughout the reticuloendothelial system. HPS may be primary, or secondary to malignancy, infections,
auto-immune diseases and pharmacotherapy. In patients with adult-onset Still’s disease (AOSD), HPS is a rare but life-threatening
complication. Herein, we described a female patient with HPS secondary to AOSD. During the therapy, giant gastric ulcer similar to lymphoma
developed after treatment with corticosteroid and nonsteroidal anti-inflammatory drugs. (IJCEP1203011).
Keywords: Adult-onset Still’s disease, hemophagocytic syndrome, giant gastric ulcer
Address all correspondence to:
Dr. Yong-Mei Han
Department of Dermatology and Rheumatology
Sir Run Run Shaw Hospital
School of Medicine, Zhejiang University
Hangzhou, China.
Tel: +86571-86002113
E-mail: hanye7899@sohu.com; E-mail: 20918097@zju.edu.cn
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