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Int J Clin Exp Pathol 2010;3(3):310-312
Case Report
Development of acute lympboblastic leukemia in a patient with increased
hematogones after toxic bone marrow damage
Stefan Gattenlöhner, Hermann Einsele
Institute of Pathology, University of Würzburg, Würzburg, Germany; Department of Internal Medicine II, University of Würzburg, Würzburg,
Germany
Received January 11, 2009; accepted January 27, 2010; available online February, 2010
Abstract: To the best of our knowledge we describe the first case showing the association of increased B cell precursors/hematogones in a
regenerating post-toxic bone marrow with subsequent development of a B-ALL. Since all immunohistochemical/moleculargenetic anaylses
have failed to identify the initial malignant leukemic clone, we suggest a close-meshed follow-up of such cases to identify potential
mechanisms for the malignant transformation of B-cell precursors/hematogones and to prevent further fatal courses. (IJCEP1001007).
Key words: Bone marrow, toxic damage, hematogones, B-ALL
Full text PDF
Address all correspondence to:
Stefan Gattenlöhner, MD
Institute of Pathology
University of Würzburg
Josef-Schneiderstr.2
D-97080 Würzburg
GERMANY
Tel.: +49(0)931-201-47420
Fax: +49(0)931-201-47440
Email: stefan.gattenloehner@mail.uni-wuerzburg.de
Case Report
Development of acute lympboblastic leukemia in a patient with increased
hematogones after toxic bone marrow damage
Stefan Gattenlöhner, Hermann Einsele
Institute of Pathology, University of Würzburg, Würzburg, Germany; Department of Internal Medicine II, University of Würzburg, Würzburg,
Germany
Received January 11, 2009; accepted January 27, 2010; available online February, 2010
Abstract: To the best of our knowledge we describe the first case showing the association of increased B cell precursors/hematogones in a
regenerating post-toxic bone marrow with subsequent development of a B-ALL. Since all immunohistochemical/moleculargenetic anaylses
have failed to identify the initial malignant leukemic clone, we suggest a close-meshed follow-up of such cases to identify potential
mechanisms for the malignant transformation of B-cell precursors/hematogones and to prevent further fatal courses. (IJCEP1001007).
Key words: Bone marrow, toxic damage, hematogones, B-ALL
Full text PDF
Address all correspondence to:
Stefan Gattenlöhner, MD
Institute of Pathology
University of Würzburg
Josef-Schneiderstr.2
D-97080 Würzburg
GERMANY
Tel.: +49(0)931-201-47420
Fax: +49(0)931-201-47440
Email: stefan.gattenloehner@mail.uni-wuerzburg.de
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