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Int J Clin Exp Pathol 2010;3(4):430-436
Case Report
An uncommon case of de novo CD10+ CD5- mantle cell lymphoma mimics follicle center
B cell lymphoma
Mauricio Zapata, Steven D. Budnick, Rodolfo Bordoni and Shiyong Li
Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA
Received February 16, 2010, accepted March 5, 2010, available online: March 20, 2010
Abstract: Mantle cell lymphoma (MCL) is a mature B-cell lymphoma characterized by expression of CD5, overexpression of Cyclin D1 as a
result of chromosomal translocation t(11;14)(q13;q32), and poor prognosis. Cases of MCL lacking CD5 expression as well as cases with
coexpression of CD5 and CD10 have also been reported. Here we describe an uncommon case of de novo MCL with expression of CD10, but
not CD5, mimicking lymphoma of germinal center-derived B cells. The lymphoma cells in this case demonstrated a diffuse pattern of
proliferation, and were strongly positive for Cyclin D1 by immunohistochemical stain. Fluorescence in situ hybridization studies demonstrated
the presence of t(11;14)(q13;q32) involving BCL1, but not chromosomal translocations involving C-MYC or BCL2, confirming the diagnosis of
MCL. This case further highlights the importance of comprehensive immunophenotypic and genetic characterization in the diagnosis and
classification of B-cell lymphomas. (IJCEP1002005).
Key words: mantle cell lymphoma, follicular lymphoma, germinal center B cell, CD10, CD5, BCL1, Cyclin D1, fluorescence in situ hybridization
Full text PDF
Address all correspondence to:
Shiyong Li, MD, PhD
Department of Pathology and Laboratory Medicine
Emory University Hospital
F143D, 1364 Clifton Road NE
Atlanta, GA 30322.
Tel: 1-404-712-5456; Fax: 1-404-712-0819
E-mail: sli2@emory.edu
Case Report
An uncommon case of de novo CD10+ CD5- mantle cell lymphoma mimics follicle center
B cell lymphoma
Mauricio Zapata, Steven D. Budnick, Rodolfo Bordoni and Shiyong Li
Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA
Received February 16, 2010, accepted March 5, 2010, available online: March 20, 2010
Abstract: Mantle cell lymphoma (MCL) is a mature B-cell lymphoma characterized by expression of CD5, overexpression of Cyclin D1 as a
result of chromosomal translocation t(11;14)(q13;q32), and poor prognosis. Cases of MCL lacking CD5 expression as well as cases with
coexpression of CD5 and CD10 have also been reported. Here we describe an uncommon case of de novo MCL with expression of CD10, but
not CD5, mimicking lymphoma of germinal center-derived B cells. The lymphoma cells in this case demonstrated a diffuse pattern of
proliferation, and were strongly positive for Cyclin D1 by immunohistochemical stain. Fluorescence in situ hybridization studies demonstrated
the presence of t(11;14)(q13;q32) involving BCL1, but not chromosomal translocations involving C-MYC or BCL2, confirming the diagnosis of
MCL. This case further highlights the importance of comprehensive immunophenotypic and genetic characterization in the diagnosis and
classification of B-cell lymphomas. (IJCEP1002005).
Key words: mantle cell lymphoma, follicular lymphoma, germinal center B cell, CD10, CD5, BCL1, Cyclin D1, fluorescence in situ hybridization
Full text PDF
Address all correspondence to:
Shiyong Li, MD, PhD
Department of Pathology and Laboratory Medicine
Emory University Hospital
F143D, 1364 Clifton Road NE
Atlanta, GA 30322.
Tel: 1-404-712-5456; Fax: 1-404-712-0819
E-mail: sli2@emory.edu
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