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Int J Clin Exp Pathol 2010;3(8):763-767
Original Article
Selective central nervous system tropism of primary central nervous system lymphoma
Liuyan Jiang, Laura A. Marlow, Simon J. Cooper, Christina V. Roemeling, David M. Menke, John A. Copland, Han W. Tun
Department of Hematology/Oncology, Mayo Clinic, Jacksonville, Florida, USA; Department of Cancer Biology, Mayo Clinic, Jacksonville, Florida,
USA; Department of Pathology, Mayo Clinic, Jacksonville, Florida; USA.
Received July 2, 2010; accepted September 29, 2010; available online October 8, 2010
Abstract: Primary Central nervous system lymphoma (PCNSL) is most frequently a diffuse large B cell lymphoma (DLBCL), which is confined
to the Central nervous system (CNS). We performed an experiment in which lymphoma cells from a PCNSL patient were implanted
subcutaneously in an athymic mouse. The lymphoma cells were shown to home to the CNS with histologic evaluations of the brain showing
multiple large B cells in bloodvessels consistent with intravascular large B cell lymphoma (IVL). We did not find any evidence of lymphoma at
the site of implantation or other locations. The findings are consistent with highly selective tropism of PCNSL for the CNS and its vasculature.
(IJCEP1007001).
Keywords: Lymphoma, central nervous system, tropism
Full text PDF
Address all correspondence to:
Han W. Tun, MD
Department of Hematology and Oncology
Mayo Clinic Florida
4500 San Pablo Road
Jacksonville, Florida 32224
Tel: 904-953-6460
Fax: 904-953-0277 Facsimile
E-mail: Tun.Han@mayo.edu
Original Article
Selective central nervous system tropism of primary central nervous system lymphoma
Liuyan Jiang, Laura A. Marlow, Simon J. Cooper, Christina V. Roemeling, David M. Menke, John A. Copland, Han W. Tun
Department of Hematology/Oncology, Mayo Clinic, Jacksonville, Florida, USA; Department of Cancer Biology, Mayo Clinic, Jacksonville, Florida,
USA; Department of Pathology, Mayo Clinic, Jacksonville, Florida; USA.
Received July 2, 2010; accepted September 29, 2010; available online October 8, 2010
Abstract: Primary Central nervous system lymphoma (PCNSL) is most frequently a diffuse large B cell lymphoma (DLBCL), which is confined
to the Central nervous system (CNS). We performed an experiment in which lymphoma cells from a PCNSL patient were implanted
subcutaneously in an athymic mouse. The lymphoma cells were shown to home to the CNS with histologic evaluations of the brain showing
multiple large B cells in bloodvessels consistent with intravascular large B cell lymphoma (IVL). We did not find any evidence of lymphoma at
the site of implantation or other locations. The findings are consistent with highly selective tropism of PCNSL for the CNS and its vasculature.
(IJCEP1007001).
Keywords: Lymphoma, central nervous system, tropism
Full text PDF
Address all correspondence to:
Han W. Tun, MD
Department of Hematology and Oncology
Mayo Clinic Florida
4500 San Pablo Road
Jacksonville, Florida 32224
Tel: 904-953-6460
Fax: 904-953-0277 Facsimile
E-mail: Tun.Han@mayo.edu
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