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Int J Clin Exp Pathol 1(1):19-31;2008
Review Article
Immunohistochemistry for Assessment of Pulmonary and Pleural Neoplasms: A Review
and Update
Dongfeng Tan and Dani S. Zander
Department of Pathology, MD Anderson Cancer Center, Houston, TX, USA and Department of Pathology, Pennsylvania State University
Hershey Medical Center, Hershey, PA, USA
Received 30 May 2007; accepted with revision 18 June 2007; available online 1 January 2008
Abstract: Diagnosis and classification of lung and pleural neoplasms are complex due to diverse histopathology and tumor heterogeneity. A
large number of immunohistochemical markers have recently become available to facilitate accurate diagnosis and classification of
pulmonary and pleural neoplasms. The purpose of this article is to review the current data available on these markers and to provide a
practical approach to evaluate pulmonary and pleural neoplasms immunohistochemically. Current literature of immunohistochemical
markers related to pulmonary and pleural neoplasms was collected and reviewed. Literature emphasizing differential diagnosis was
selected. Data useful in the diagnosis and classification of pulmonary and pleural neoplasms was collated. This review provides an updated
overview and general guideline for the practicing surgical pathologists to resolve some of the common differential diagnostic situations in
their daily immunohistochemical assessment of pulmonary and pleural neoplasms. (IJCEP704003).
Key Words: Immunohistochemistry, lung, small cell carcinoma, adenocarcinoma, non-small cell carcinoma, pleura, adenocarcinoma,
mesothelioma, neuroendocrine neoplasm, spindle cell neoplasm
Full Text: PDF
Address all correspondence to: Dongfeng Tan, MD, Department of Pathology, Unit 85, MD Anderson Cancer Center, 1515 Holcombe
Blvd., Houston, TX 77030, USA. Tel: 713-745-4977, Fax: 713-745-1105, Email: dtan@mdanderson.org.
Review Article
Immunohistochemistry for Assessment of Pulmonary and Pleural Neoplasms: A Review
and Update
Dongfeng Tan and Dani S. Zander
Department of Pathology, MD Anderson Cancer Center, Houston, TX, USA and Department of Pathology, Pennsylvania State University
Hershey Medical Center, Hershey, PA, USA
Received 30 May 2007; accepted with revision 18 June 2007; available online 1 January 2008
Abstract: Diagnosis and classification of lung and pleural neoplasms are complex due to diverse histopathology and tumor heterogeneity. A
large number of immunohistochemical markers have recently become available to facilitate accurate diagnosis and classification of
pulmonary and pleural neoplasms. The purpose of this article is to review the current data available on these markers and to provide a
practical approach to evaluate pulmonary and pleural neoplasms immunohistochemically. Current literature of immunohistochemical
markers related to pulmonary and pleural neoplasms was collected and reviewed. Literature emphasizing differential diagnosis was
selected. Data useful in the diagnosis and classification of pulmonary and pleural neoplasms was collated. This review provides an updated
overview and general guideline for the practicing surgical pathologists to resolve some of the common differential diagnostic situations in
their daily immunohistochemical assessment of pulmonary and pleural neoplasms. (IJCEP704003).
Key Words: Immunohistochemistry, lung, small cell carcinoma, adenocarcinoma, non-small cell carcinoma, pleura, adenocarcinoma,
mesothelioma, neuroendocrine neoplasm, spindle cell neoplasm
Full Text: PDF
Address all correspondence to: Dongfeng Tan, MD, Department of Pathology, Unit 85, MD Anderson Cancer Center, 1515 Holcombe
Blvd., Houston, TX 77030, USA. Tel: 713-745-4977, Fax: 713-745-1105, Email: dtan@mdanderson.org.
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