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| IJCEP Copyright © 2007-All rights reserved. |
| International Journal of Clinical and Experimental Pathology |
Int J Clin Exp Pathol 1(5):457-460;2008.
Case Report
Invasive Micropapillary Carcinoma of the Sigmoid Colon: Distinct Morphology and
Aggressive Behavior
Ping Wen, Yiqing Xu, Wendy L. Frankel and Rulong Shen
Departments of Pathology (Drs Shen, Frankel, and Wen) and Internal Medicine (Dr. Xu), The Ohio State University Medical Center,
Columbus, Ohio, USA
Received 6 Sept 2007; accepted and available online 1 January 2008
Abstract: We report a case of invasive micropapillary carcinoma of the sigmoid colon in a 72-year-old female with anemia and abdominal
pain. Grossly, the tumor demonstrated a deeply invasive, ulcerated fungating mass. Microscopically, the carcinoma was predominantly
composed of micropapillae with reversed cell polarity, abundant neutrophils, and surrounded by clear spaces. Multifocal lymphovascular
invasion was present with extensive lymph node metastasis. Immunohistochemically, the carcinoma cells were positive for CDX2, CK20
and monoclonal carcinoembryonic antigen. They were negative for CK7. The stroma-facing surface of the micropapillae was positive for
CD10 and villin, confirming the inside-out growth pattern characteristic of micropapillary carcinoma. Work-up for distance metastasis was
negative. The patient was alive and well 1.5 years after sigmoidectomy and postoperative chemotherapy. (IJCEP709003).
Key Words: Adenocarcinoma, micropapillary, invasive, metastasis, colon
Full Text PDF
Address all correspondences to: Rulong Shen, MD, The Ohio State University Medical Center, S305 Rhodes Hall, 410 W Tenth Avenue,
Columbus, Ohio 43210, Telephone: (614) 293-8946, Fax: (614) 293-8747, Email: rulong.shen@osumc.edu
Case Report
Invasive Micropapillary Carcinoma of the Sigmoid Colon: Distinct Morphology and
Aggressive Behavior
Ping Wen, Yiqing Xu, Wendy L. Frankel and Rulong Shen
Departments of Pathology (Drs Shen, Frankel, and Wen) and Internal Medicine (Dr. Xu), The Ohio State University Medical Center,
Columbus, Ohio, USA
Received 6 Sept 2007; accepted and available online 1 January 2008
Abstract: We report a case of invasive micropapillary carcinoma of the sigmoid colon in a 72-year-old female with anemia and abdominal
pain. Grossly, the tumor demonstrated a deeply invasive, ulcerated fungating mass. Microscopically, the carcinoma was predominantly
composed of micropapillae with reversed cell polarity, abundant neutrophils, and surrounded by clear spaces. Multifocal lymphovascular
invasion was present with extensive lymph node metastasis. Immunohistochemically, the carcinoma cells were positive for CDX2, CK20
and monoclonal carcinoembryonic antigen. They were negative for CK7. The stroma-facing surface of the micropapillae was positive for
CD10 and villin, confirming the inside-out growth pattern characteristic of micropapillary carcinoma. Work-up for distance metastasis was
negative. The patient was alive and well 1.5 years after sigmoidectomy and postoperative chemotherapy. (IJCEP709003).
Key Words: Adenocarcinoma, micropapillary, invasive, metastasis, colon
Full Text PDF
Address all correspondences to: Rulong Shen, MD, The Ohio State University Medical Center, S305 Rhodes Hall, 410 W Tenth Avenue,
Columbus, Ohio 43210, Telephone: (614) 293-8946, Fax: (614) 293-8747, Email: rulong.shen@osumc.edu