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| IJCEP Copyright © 2007-All rights reserved. |
| International Journal of Clinical and Experimental Pathology |
Int J Clin Exp Pathol 1(4):306-316;2008
Review Article
Update on Pancreatic Intraepithelial Neoplasia
Ralph Hruban, Anirban Maitra and Michael Goggins
The Sol Goldman Pancreatic Cancer Research Center, the Departments of Pathology, Oncology and Medicine, and the Institute for
Genetic Medicine, the Johns Hopkins Medical Institutions, Baltimore, Maryland
Received 28 Sept 2007; available online 1 January 2008
Abstract: Pancreatic intraepithelial neoplasia (PanIN) is a histologically well-defined precursor to invasive ductal adenocarcinoma of the
pancreas. PanINs are remarkably common lesions, particularly in the elderly population. Molecular studies have helped establish the
progression of PanIN to invasive cancer, and recently genetically engineered mouse models have been generated that recapitulate the
entire spectrum of lesions from precursor to invasive pancreatic cancer. Some PanIN lesions produce lobulocentric atrophy of the
pancreatic parenchyma, and, when multifocal, this lobulocentric atrophy may be detectable using currently available imaging techniques
such as endoscopic ultrasound. The association of acinar-ductal metaplasia with PanIN lesions has led some to hypothesize that
PanINs develop from acinar cells that undergo acinar-ductal metaplasia.(IJCEP709011).
Key Words: Pancreatic cancer, intraepithelial neoplasm, metaplasia, genetics, epigenetics
Full Text PDF
Address all correspondences to: Ralph Hruban, M.D., The Sol Goldman Pancreatic Cancer Research Center, Weinberg 2242, The
Johns Hopkins Medical Institutions, 401 North Broadway, Baltimore, MD 21231. Phone: 410-955-9132, Fax: 410-955-0115,
Email: rhruban@jhmi.edu.
Review Article
Update on Pancreatic Intraepithelial Neoplasia
Ralph Hruban, Anirban Maitra and Michael Goggins
The Sol Goldman Pancreatic Cancer Research Center, the Departments of Pathology, Oncology and Medicine, and the Institute for
Genetic Medicine, the Johns Hopkins Medical Institutions, Baltimore, Maryland
Received 28 Sept 2007; available online 1 January 2008
Abstract: Pancreatic intraepithelial neoplasia (PanIN) is a histologically well-defined precursor to invasive ductal adenocarcinoma of the
pancreas. PanINs are remarkably common lesions, particularly in the elderly population. Molecular studies have helped establish the
progression of PanIN to invasive cancer, and recently genetically engineered mouse models have been generated that recapitulate the
entire spectrum of lesions from precursor to invasive pancreatic cancer. Some PanIN lesions produce lobulocentric atrophy of the
pancreatic parenchyma, and, when multifocal, this lobulocentric atrophy may be detectable using currently available imaging techniques
such as endoscopic ultrasound. The association of acinar-ductal metaplasia with PanIN lesions has led some to hypothesize that
PanINs develop from acinar cells that undergo acinar-ductal metaplasia.(IJCEP709011).
Key Words: Pancreatic cancer, intraepithelial neoplasm, metaplasia, genetics, epigenetics
Full Text PDF
Address all correspondences to: Ralph Hruban, M.D., The Sol Goldman Pancreatic Cancer Research Center, Weinberg 2242, The
Johns Hopkins Medical Institutions, 401 North Broadway, Baltimore, MD 21231. Phone: 410-955-9132, Fax: 410-955-0115,
Email: rhruban@jhmi.edu.