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| IJCEP Copyright © 2007-All rights reserved. |
| International Journal of Clinical and Experimental Pathology |
Int J Clin Exp Pathol 2(1):83-90;2009
Original Article
Correlation of Macrophage Inflammatory Protein-2 Expression and Brain Edema in
Rats after Intracerebral Hemorrhage
He Wu, Yuwei Cong, Dandan Wang, Ruibo Zhao and Jiping Qi
Department of Pathology, First Clinical Hospital, Harbin Medical University, Harbin 150001, PR China; Department of Pathology, the
Second Affiliated Hospital of Tsinghua University, Beijing 100049, PR China and Pathology Centralab, Harbin Medical University, Harbin
150086, PR China
Received 10 March 2008; Accepted in revision 22 May 2008; Available online 2 June 2008
Abstract: Brain edema is one of the most frequent and serious complications of intracerebral hemorrhage (ICH), but its underlying
mechanism remains largely unknown. In order to understand whether inflammatory mediators released from the blood after cerebral
hemorrhage plays a role in brain edema, we investigated the dynamic change of the inflammatory mediator macrophage inflammatory
protein-2 (MIP-2) in rat brain after ICH. Our results indicate that the expression of MIP-2 increases 2 hours and peaks 2 days after ICH.
The expression of MIP-2 correlates with NF-κB activation and brain water content. These results suggest that MIP-2 expression may play
an important role in the development of brain edema after ICH in rats. (IJCEP803001).
Key Words: MIP-2, NF-κB, brain edema, intracerebral hemorrhage
Full text PDF.
Address all correspondences to: Jiping Qi, Department of Pathology, First Clinical Hospital, Harbin Medical University, Harbin 150001,
PR China. Email: qi_jiping@hotmail.com
Original Article
Correlation of Macrophage Inflammatory Protein-2 Expression and Brain Edema in
Rats after Intracerebral Hemorrhage
He Wu, Yuwei Cong, Dandan Wang, Ruibo Zhao and Jiping Qi
Department of Pathology, First Clinical Hospital, Harbin Medical University, Harbin 150001, PR China; Department of Pathology, the
Second Affiliated Hospital of Tsinghua University, Beijing 100049, PR China and Pathology Centralab, Harbin Medical University, Harbin
150086, PR China
Received 10 March 2008; Accepted in revision 22 May 2008; Available online 2 June 2008
Abstract: Brain edema is one of the most frequent and serious complications of intracerebral hemorrhage (ICH), but its underlying
mechanism remains largely unknown. In order to understand whether inflammatory mediators released from the blood after cerebral
hemorrhage plays a role in brain edema, we investigated the dynamic change of the inflammatory mediator macrophage inflammatory
protein-2 (MIP-2) in rat brain after ICH. Our results indicate that the expression of MIP-2 increases 2 hours and peaks 2 days after ICH.
The expression of MIP-2 correlates with NF-κB activation and brain water content. These results suggest that MIP-2 expression may play
an important role in the development of brain edema after ICH in rats. (IJCEP803001).
Key Words: MIP-2, NF-κB, brain edema, intracerebral hemorrhage
Full text PDF.
Address all correspondences to: Jiping Qi, Department of Pathology, First Clinical Hospital, Harbin Medical University, Harbin 150001,
PR China. Email: qi_jiping@hotmail.com