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| IJCEP Copyright © 2007-All rights reserved. |
| International Journal of Clinical and Experimental Pathology |
Int J Clin Exp Pathol 2(3),300-302;2009
Case Report
An Unusually Large Granular Cell Tumor of the Pharynx: A Case Report and
Literature Review
Xiaoxian Li, Robert B. Parke Jr., Jennifer R. Rushton, Anna Sienko and Qihui “Jim” Zhai
Department of Pathology, The Methodist Hospital, Houston, TX and Bobby R. Alford Department of Otolaryngology - Head and Neck
Surgery and Department of Pathology, Baylor College of Medicine, Houston, TX
Received 6 August 2008; Accepted 9 September 2008; Available online 1 October 2008
Abstract: We report a granular cell tumor of the pharynx in a 53 year-old woman who presented with a large retropharyngeal mass.
Surgical excision revealed a 5.5 cm tan rubbery unencapsulated but circumscribed mass. Histologically, the tumor is composed of
diffusely arranged oval and spindle cells with abundant eosinophilic granular cytoplasm and mildly pleomorphic nuclei without necrosis
or mitoses. Immunostains show the tumor cells to be positive for S-100, vimentin, non-specific esterase and focally positive for inhibin. In
addition to its unusual location, this tumor is extremely large while most granular cell tumors are small (<2 cm). This case represents a
unique example of a large granular cell tumor at a rare location: the pharynx. (IJCEP808001).
Key Words: Granular cell tumor, pharynx
Full text PDF
Address all correspondences to: Qihui “Jim” Zhai, MD, Department of Pathology, The Methodist Hospital, Houston, TX 77030. E-mail:
qzhai@tmhs.org
Case Report
An Unusually Large Granular Cell Tumor of the Pharynx: A Case Report and
Literature Review
Xiaoxian Li, Robert B. Parke Jr., Jennifer R. Rushton, Anna Sienko and Qihui “Jim” Zhai
Department of Pathology, The Methodist Hospital, Houston, TX and Bobby R. Alford Department of Otolaryngology - Head and Neck
Surgery and Department of Pathology, Baylor College of Medicine, Houston, TX
Received 6 August 2008; Accepted 9 September 2008; Available online 1 October 2008
Abstract: We report a granular cell tumor of the pharynx in a 53 year-old woman who presented with a large retropharyngeal mass.
Surgical excision revealed a 5.5 cm tan rubbery unencapsulated but circumscribed mass. Histologically, the tumor is composed of
diffusely arranged oval and spindle cells with abundant eosinophilic granular cytoplasm and mildly pleomorphic nuclei without necrosis
or mitoses. Immunostains show the tumor cells to be positive for S-100, vimentin, non-specific esterase and focally positive for inhibin. In
addition to its unusual location, this tumor is extremely large while most granular cell tumors are small (<2 cm). This case represents a
unique example of a large granular cell tumor at a rare location: the pharynx. (IJCEP808001).
Key Words: Granular cell tumor, pharynx
Full text PDF
Address all correspondences to: Qihui “Jim” Zhai, MD, Department of Pathology, The Methodist Hospital, Houston, TX 77030. E-mail:
qzhai@tmhs.org