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Int J Clin Exp Pathol 2(6),599-601;2009
Case Report
Bacillus Calmette-Guerin Granuloma in Seminal Vesicle: Report of the First Case in the
English Literature
Kyungeun Kim, Yong Mee Cho, Young Ok Hong, Sun A Kim and Jae Y. Ro
Department of Pathology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, South Korea; Department of pathology,
University of Eulji college of medicine, Eulji general hospital, Seoul, Korea and Department of Pathology, The Methodist Hospital, Weill Medical
College of Cornell University, Houston, TX, USA
Received 25 February 2009; Accepted 13 March 2009; Available online 20 March 2009
Abstract: A 64-year-old man underwent a radical cystoprostatectomy for intravesical bacillus Calmette-Guerin (BCG) therapy-resistant,
recurrent muscle invasive transitional cell carcinoma (TCC) of the urinary bladder. He had a history of left radical nephroureterectomy for a
papillary TCC of the left ureter 10 months ago. On microscopic examination, not only multifocal residual papillary TCCs in the urinary bladder
but also multiple small granulomas in the urinary bladder and prostate were noted. Interestingly, unusually severe granulomatous
inflammation accompanying focal central caseating necrosis was identified in the subepithelial tissue of the left seminal vesicle and vas
deferens. Neither prostatic adenocarcinoma nor TCC involvement was identified in the prostate and seminal vesicles. A few acid–fast bacilli
were identified by the Ziehl-Neelsen staining in the seminal vesicle granulomas, confirming the BCG-induced inflammation. To the best of our
knowledge, this is the first case of BCG-induced granuloma involving the seminal vesicle. It is uncertain why only the left seminal vesicle was
involved with BCG granulomas and the incidence and mechanism of seminal vesicle BCG granuloma await more cases. (IJCEP902006).
Key Words: Bacillus Calmette-Guerin, BCG, seminal vesicles, granuloma
Full text PDF
Address all correspondence to: Jae Y. Ro, MD, Department of Pathology, University of Ulsan College of Medicine, Asan Medical Center, 388-1
Pungnap-dong, Songpa-gu, Seoul 138-736, Korea. Tel: 02-3010-4560; Fax: 02-472-7898; Email: JaeRo@tmhs.org
Case Report
Bacillus Calmette-Guerin Granuloma in Seminal Vesicle: Report of the First Case in the
English Literature
Kyungeun Kim, Yong Mee Cho, Young Ok Hong, Sun A Kim and Jae Y. Ro
Department of Pathology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, South Korea; Department of pathology,
University of Eulji college of medicine, Eulji general hospital, Seoul, Korea and Department of Pathology, The Methodist Hospital, Weill Medical
College of Cornell University, Houston, TX, USA
Received 25 February 2009; Accepted 13 March 2009; Available online 20 March 2009
Abstract: A 64-year-old man underwent a radical cystoprostatectomy for intravesical bacillus Calmette-Guerin (BCG) therapy-resistant,
recurrent muscle invasive transitional cell carcinoma (TCC) of the urinary bladder. He had a history of left radical nephroureterectomy for a
papillary TCC of the left ureter 10 months ago. On microscopic examination, not only multifocal residual papillary TCCs in the urinary bladder
but also multiple small granulomas in the urinary bladder and prostate were noted. Interestingly, unusually severe granulomatous
inflammation accompanying focal central caseating necrosis was identified in the subepithelial tissue of the left seminal vesicle and vas
deferens. Neither prostatic adenocarcinoma nor TCC involvement was identified in the prostate and seminal vesicles. A few acid–fast bacilli
were identified by the Ziehl-Neelsen staining in the seminal vesicle granulomas, confirming the BCG-induced inflammation. To the best of our
knowledge, this is the first case of BCG-induced granuloma involving the seminal vesicle. It is uncertain why only the left seminal vesicle was
involved with BCG granulomas and the incidence and mechanism of seminal vesicle BCG granuloma await more cases. (IJCEP902006).
Key Words: Bacillus Calmette-Guerin, BCG, seminal vesicles, granuloma
Full text PDF
Address all correspondence to: Jae Y. Ro, MD, Department of Pathology, University of Ulsan College of Medicine, Asan Medical Center, 388-1
Pungnap-dong, Songpa-gu, Seoul 138-736, Korea. Tel: 02-3010-4560; Fax: 02-472-7898; Email: JaeRo@tmhs.org
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