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Int J Clin Exp Pathol 2(6),608-613;2009
Case Report
Gastrointestinal Stromal Tumor with Autonomic Nerve Differentiation and Coexistent
Mantle Cell Lymphoma Involving the Appendix
Kurosh Rahimi, Adrian Gologan, Tina Haliotis, Esther Lamoureux and Runjan Chetty
Departments of Pathology, The Jewish General Hospital, Montreal and University Health Network, University of Toronto, Toronto, Canada
Received 24 March 2009; Accepted in revision 28 March 2008; Available online 20 May 2009
Abstract: Gastrointestinal stromal tumor (GIST) and mantle cell lymphoma involving the appendix are rare as individual disease entities. Their
coexistence has not been previously reported in the literature. We describe a 65-year old female who presented with extensive ileocecal mantle
cell lymphoma, which extended to the appendix. The appendix was involved by mantle cell lymphoma and an incidental coexistent GIST was
noted in the appendiceal wall. The GIST was CD117 positive but did not harbor mutations in the c-kit and PDGFR genes. In addition, it was
unusual in showing S-100 immunoreactivity and ultrastructural evidence of autonomic nerve differentiation. This is the first description of the
association of a GIST with autonomic nerve differentiation coexisting with mantle cell lymphoma in the appendix. (IJCEP903006).
Key Words: Gastrointestinal stromal tumor, gastrointestinal autonomic nerve tumor, mantle cell lymphoma, appendix
Full text PDF
Address all correspondence to: Runjan Chetty, MD, Department of Pathology, Laboratory Medicine Programme, University Health Network,
The Toronto General Hospital, 200 Elizabeth Street, 11th Floor, Eaton Wing, Toronto, Ontario, M5G 2C4, Canada. Tel: 1-416-340-3661; Fax:
1-416-340-5517; Email: runjan.chetty@uhn.on.ca
Case Report
Gastrointestinal Stromal Tumor with Autonomic Nerve Differentiation and Coexistent
Mantle Cell Lymphoma Involving the Appendix
Kurosh Rahimi, Adrian Gologan, Tina Haliotis, Esther Lamoureux and Runjan Chetty
Departments of Pathology, The Jewish General Hospital, Montreal and University Health Network, University of Toronto, Toronto, Canada
Received 24 March 2009; Accepted in revision 28 March 2008; Available online 20 May 2009
Abstract: Gastrointestinal stromal tumor (GIST) and mantle cell lymphoma involving the appendix are rare as individual disease entities. Their
coexistence has not been previously reported in the literature. We describe a 65-year old female who presented with extensive ileocecal mantle
cell lymphoma, which extended to the appendix. The appendix was involved by mantle cell lymphoma and an incidental coexistent GIST was
noted in the appendiceal wall. The GIST was CD117 positive but did not harbor mutations in the c-kit and PDGFR genes. In addition, it was
unusual in showing S-100 immunoreactivity and ultrastructural evidence of autonomic nerve differentiation. This is the first description of the
association of a GIST with autonomic nerve differentiation coexisting with mantle cell lymphoma in the appendix. (IJCEP903006).
Key Words: Gastrointestinal stromal tumor, gastrointestinal autonomic nerve tumor, mantle cell lymphoma, appendix
Full text PDF
Address all correspondence to: Runjan Chetty, MD, Department of Pathology, Laboratory Medicine Programme, University Health Network,
The Toronto General Hospital, 200 Elizabeth Street, 11th Floor, Eaton Wing, Toronto, Ontario, M5G 2C4, Canada. Tel: 1-416-340-3661; Fax:
1-416-340-5517; Email: runjan.chetty@uhn.on.ca
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