| IJCEP Copyright © 2007-All rights reserved. |
Int J Clin Exp Pathol 2(6),544-552;2009
Review Article
The Role of T Cells in Osteoporosis, an Update
Wen Zhao, Yuying Liu, Catherine M. Cahill, Wenlu Yang, Jack T. Rogers, Xudong Huang
1Department of Orthopedics, Beijing Aerospace General Hospital, Beijing, China; 2Department of Biochemistry and Molecular Biology, Medical
University of South Carolina, Charleston, SC, USA; 3Neurochemistry Laboratory, Department of Psychiatry, Massachusetts General Hospital
(MGH) and Harvard Medical School, Charlestown, MA, USA; 4Conjugate and Medicinal Chemistry Laboratory, Division of Nuclear Medicine and
Molecular Imaging, Department of Radiology, Brigham and Women’s Hospital (BWH) and Harvard Medical School, Boston, MA, USA and
5Department of Electrical Engineering, Information Engineering College, Shanghai Maritime University, Shanghai, China
Received 29 April 2009; Accepted 16 May 2009; Available online 20 May 2009
Abstract: Emerging evidence highlights the importance of the interplay between the bone and immune systems. That evidence bolsters a
longstanding recognition that estrogen deficiency, infection, inflammation, and autoimmune disorders are associated with systemic and local
bone loss. Yet, only recently has an understanding emerged that T lymphocytes and their products act as key regulators of osteoclast
formation, life span, and activity. This review presents this understanding of the process of T lymphocytes and their products mediating
osteoporosis and explores some of the most recent findings and hypotheses to explain their action in bone. A more complete appreciation of
the interactions between immune and bone cells should lead to targeted therapeutic strategies for diseases that affect either or both systems.
(IJCEP904011).
Key Words: Osteoporosis, T cells, osteoclast, osteoclastogenesis, cytokine, chemokine
Full text PDF
Address all correspondence to: Xudong Huang, PhD, Director of Conjugate and Medicinal Chemistry Laboratory, 75 Francis Street,
Department of Radiology, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA 02115, USA. Tel: 617-582-4711; Fax: 617-
582-0004; Email: xhuang3@partners.org
Review Article
The Role of T Cells in Osteoporosis, an Update
Wen Zhao, Yuying Liu, Catherine M. Cahill, Wenlu Yang, Jack T. Rogers, Xudong Huang
1Department of Orthopedics, Beijing Aerospace General Hospital, Beijing, China; 2Department of Biochemistry and Molecular Biology, Medical
University of South Carolina, Charleston, SC, USA; 3Neurochemistry Laboratory, Department of Psychiatry, Massachusetts General Hospital
(MGH) and Harvard Medical School, Charlestown, MA, USA; 4Conjugate and Medicinal Chemistry Laboratory, Division of Nuclear Medicine and
Molecular Imaging, Department of Radiology, Brigham and Women’s Hospital (BWH) and Harvard Medical School, Boston, MA, USA and
5Department of Electrical Engineering, Information Engineering College, Shanghai Maritime University, Shanghai, China
Received 29 April 2009; Accepted 16 May 2009; Available online 20 May 2009
Abstract: Emerging evidence highlights the importance of the interplay between the bone and immune systems. That evidence bolsters a
longstanding recognition that estrogen deficiency, infection, inflammation, and autoimmune disorders are associated with systemic and local
bone loss. Yet, only recently has an understanding emerged that T lymphocytes and their products act as key regulators of osteoclast
formation, life span, and activity. This review presents this understanding of the process of T lymphocytes and their products mediating
osteoporosis and explores some of the most recent findings and hypotheses to explain their action in bone. A more complete appreciation of
the interactions between immune and bone cells should lead to targeted therapeutic strategies for diseases that affect either or both systems.
(IJCEP904011).
Key Words: Osteoporosis, T cells, osteoclast, osteoclastogenesis, cytokine, chemokine
Full text PDF
Address all correspondence to: Xudong Huang, PhD, Director of Conjugate and Medicinal Chemistry Laboratory, 75 Francis Street,
Department of Radiology, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA 02115, USA. Tel: 617-582-4711; Fax: 617-
582-0004; Email: xhuang3@partners.org
 | |  | |  | |  | |  | |  |
