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Int J Clin Exp Pathol 2010;3(1):39-46
Review Article
Pitfalls in Diagnostic Hematopathology – Part II
Xianfeng F. Zhao
Department of Pathology, University of Maryland School of Medicine, Baltimore, MD
Received June 18, 2009; accepted August 20, 2009; Available online September 10, 2009
Abstract: The overlapping features of malignant lymphomas create a diagnostic “grey zone”, and lead to the invention of “grey zone
lymphomas”. There are several major grey zone lymphomas: 1) Lymphomas with overlapping features of Hodgkin lymphoma and large B-cell
lymphoma; 2) Lymphomas with overlapping features of Burkitt lymphoma and diffuse large B-cell lymphoma; 3) Lymphomas with overlapping
features of nodular lymphocyte predominant Hodgkin lymphoma and T-cell/histiocyte rich large B-cell lymphoma; 4) Lymphomas with
overlapping features of Hodgkin lymphoma, anaplastic large cell lymphoma (ALCL) and peripheral T-cell lymphoma (PTCL); 5) T-cell classical
Hodgkin lymphoma and ALCL-HL. The second review of this series will be dedicated to discussion of the “grey zone” features of the
lymphomas and how to narrow down the “grey zone” between those lymphomas. (IJCEP906002).
Key words: DLBCL, Hodgkin lymphoma, Burkitt lymphoma, grey zone lymphoma, diagnostic pitfalls
Full text PDF
Address all correspondence to:
X. Frank Zhao, MD, PhD
Department of Pathology
University of Maryland School of Medicine
10 S. Pine Street, MSTF 611B
Baltimore, MD 21201
Tel: 410-328-2146
Fax: 410-328-5508
E-mail: xzhao@umm.edu
Review Article
Pitfalls in Diagnostic Hematopathology – Part II
Xianfeng F. Zhao
Department of Pathology, University of Maryland School of Medicine, Baltimore, MD
Received June 18, 2009; accepted August 20, 2009; Available online September 10, 2009
Abstract: The overlapping features of malignant lymphomas create a diagnostic “grey zone”, and lead to the invention of “grey zone
lymphomas”. There are several major grey zone lymphomas: 1) Lymphomas with overlapping features of Hodgkin lymphoma and large B-cell
lymphoma; 2) Lymphomas with overlapping features of Burkitt lymphoma and diffuse large B-cell lymphoma; 3) Lymphomas with overlapping
features of nodular lymphocyte predominant Hodgkin lymphoma and T-cell/histiocyte rich large B-cell lymphoma; 4) Lymphomas with
overlapping features of Hodgkin lymphoma, anaplastic large cell lymphoma (ALCL) and peripheral T-cell lymphoma (PTCL); 5) T-cell classical
Hodgkin lymphoma and ALCL-HL. The second review of this series will be dedicated to discussion of the “grey zone” features of the
lymphomas and how to narrow down the “grey zone” between those lymphomas. (IJCEP906002).
Key words: DLBCL, Hodgkin lymphoma, Burkitt lymphoma, grey zone lymphoma, diagnostic pitfalls
Full text PDF
Address all correspondence to:
X. Frank Zhao, MD, PhD
Department of Pathology
University of Maryland School of Medicine
10 S. Pine Street, MSTF 611B
Baltimore, MD 21201
Tel: 410-328-2146
Fax: 410-328-5508
E-mail: xzhao@umm.edu
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