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Int J Clin Exp Pathol 2010;3(1):1-23
Review Article
Neuropathology of non-Alzheimer degenerative disorders
Dennis W. Dickson
Department of Neuroscience, Mayo Clinic, Jacksonville, Florida, USA
Received August 23, 2009; accepted August 24, 2009; Available online August 25, 2009
Abstract: Neurodegenerative diseases are characterized by selective and progressive loss of specific populations of neurons, which
determines the clinical presentation. The same neuronal populations can be affected in a number of different disorders. Given that the clinical
presentation reflects the particular population of neurons that are targets of the disease process, it is clear that for any given clinical syndrome,
more than one neurodegenerative disease can account for the clinical syndrome. Because of this clinical ambiguity, for the purpose of this brief
review neurodegenerative disorders are classified according to the underlying molecular pathology rather than their clinical presentation. The
major neurodegenerative diseases can be classified into amyloidoses, tauopathies, α-synucleinopathies and TDP-43 proteinopathies.
(IJCEP908006).
Key words: Amyloidosis, tauopathy, synucleinopathy, TDP-43 proteinopathy
Full text PDF
Address all correspondence to:
Dennis W. Dickson, MD
Neuropathology Laboratory
Mayo Clinic
4500 San Pablo Road
Jacksonville, FL. 32224
Tel: 904-953-7137, Fax: 904-953-7117
E-mail: dickson.dennis@mayo.edu
Review Article
Neuropathology of non-Alzheimer degenerative disorders
Dennis W. Dickson
Department of Neuroscience, Mayo Clinic, Jacksonville, Florida, USA
Received August 23, 2009; accepted August 24, 2009; Available online August 25, 2009
Abstract: Neurodegenerative diseases are characterized by selective and progressive loss of specific populations of neurons, which
determines the clinical presentation. The same neuronal populations can be affected in a number of different disorders. Given that the clinical
presentation reflects the particular population of neurons that are targets of the disease process, it is clear that for any given clinical syndrome,
more than one neurodegenerative disease can account for the clinical syndrome. Because of this clinical ambiguity, for the purpose of this brief
review neurodegenerative disorders are classified according to the underlying molecular pathology rather than their clinical presentation. The
major neurodegenerative diseases can be classified into amyloidoses, tauopathies, α-synucleinopathies and TDP-43 proteinopathies.
(IJCEP908006).
Key words: Amyloidosis, tauopathy, synucleinopathy, TDP-43 proteinopathy
Full text PDF
Address all correspondence to:
Dennis W. Dickson, MD
Neuropathology Laboratory
Mayo Clinic
4500 San Pablo Road
Jacksonville, FL. 32224
Tel: 904-953-7137, Fax: 904-953-7117
E-mail: dickson.dennis@mayo.edu
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