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Int J Clin Exp Pathol 2010;3(1):117-127
Case Report
Silicone implant and primary breast ALK1-negativeanaplastic large cell lymphoma, fact
or fiction?
Shiyong Li, Andrew K Lee
Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA, USA
Received October 1, 2009, accepted October 12, 2009, available online October 15, 2009
Abstract: The safety of silicone-based implant for mammoplasty has been debated for decades. A series of anecdotal case reports and a
recent epidemiological case-control study have suggested a possible association between silicone implant and the development of primary
breast ALK1-negative anaplastic large cell lymphoma (ALCL), a rare type of peripheral T-cell lymphoma. In this report, we describe an
additional case of primary breast ALK1-negative ALCL in the fibrous capsule and cystic fluid of silicone breast implant in a 58 year old woman
who underwent breast reconstructive surgery after lumpectomy for her infiltrating breast adenocarcinoma. Morphologically and
immunohistochemically, the lymphoma cells may be confused with recurrent infiltrating breast adenocarcinoma or other nonhematolymphoid
malignancies. Molecular studies were needed to determine T-lineage differentiation of the malignant lymphoma cells. We will also review the
case reports and case series published in the English literature and discuss our current understanding of silicone implant in primary breast
ALK1-negative ALCL. (IJCEP910002).
Key words: Breast implant, silicone, anaplastic large cell lymphoma, ALK1, ALCL
Full text PDF
Address all correspondence to:
Shiyong Li, MD, PhD
Department of Pathology and Laboratory Medicine
Emory University Hospital F143D, 1364 Clifton Road NE
Atlanta, GA 30322, USA.
Tel: 1-404-712-5456; Fax: 1-404-712-0819
E-mail: sli2@emory.edu
Case Report
Silicone implant and primary breast ALK1-negativeanaplastic large cell lymphoma, fact
or fiction?
Shiyong Li, Andrew K Lee
Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA, USA
Received October 1, 2009, accepted October 12, 2009, available online October 15, 2009
Abstract: The safety of silicone-based implant for mammoplasty has been debated for decades. A series of anecdotal case reports and a
recent epidemiological case-control study have suggested a possible association between silicone implant and the development of primary
breast ALK1-negative anaplastic large cell lymphoma (ALCL), a rare type of peripheral T-cell lymphoma. In this report, we describe an
additional case of primary breast ALK1-negative ALCL in the fibrous capsule and cystic fluid of silicone breast implant in a 58 year old woman
who underwent breast reconstructive surgery after lumpectomy for her infiltrating breast adenocarcinoma. Morphologically and
immunohistochemically, the lymphoma cells may be confused with recurrent infiltrating breast adenocarcinoma or other nonhematolymphoid
malignancies. Molecular studies were needed to determine T-lineage differentiation of the malignant lymphoma cells. We will also review the
case reports and case series published in the English literature and discuss our current understanding of silicone implant in primary breast
ALK1-negative ALCL. (IJCEP910002).
Key words: Breast implant, silicone, anaplastic large cell lymphoma, ALK1, ALCL
Full text PDF
Address all correspondence to:
Shiyong Li, MD, PhD
Department of Pathology and Laboratory Medicine
Emory University Hospital F143D, 1364 Clifton Road NE
Atlanta, GA 30322, USA.
Tel: 1-404-712-5456; Fax: 1-404-712-0819
E-mail: sli2@emory.edu
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