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Int J Clin Exp Pathol 2(6),553-560;2009
Original Article
Immunoreactivity of ICAM-1 in Human Tumors, Metastases and Normal Tissues
Sarah H. Hayes and Gail M. Seigel
Department of Ophthalmology, Ross Eye Institute, University at Buffalo, Buffalo, NY
Received 06 April 2009; Accepted in revision 18 May 2009; Available online 10 June 2009
Abstract: Intercellular adhesion molecule-1 (ICAM-1) is implicated to play a role in cancer metastasis, and may serve as a diagnostic tool for
tumor prognosis and progression as well as a target for therapeutic intervention. The aim of this study was to carry out a comprehensive survey
of ICAM-1 immunoreactivity in normal, malignant and metastatic tissues. We assessed immunoreactivity of ICAM-1 in a total of 300 tissue
cores from multiple tissue arrays of normal, malignant, and metastatic tissues by immunohistochemistry. We scored tissue samples for
ICAM-1 immunoreactivity on a 0-3 scale, assessed the number of samples exhibiting infiltrating immune cells, and documented ICAM-1
immunoreactivity in some specific cell types. ICAM-1 expression in normal tissues was highest in spleen and absent in the cerebrum,
peripheral nerves, pancreas, ovary, breast, uterus, cervix, prostate, lung, larynx, bone marrow, striated muscle, heart, mesothelium,
esophagus, small intestine, colon and liver. In primary malignancies, lymphoid tissues received the highest average ICAM-1 score while
connective tissue/skin had the lowest average ICAM-1 score. Of the metastatic tissues, those originating from the urinary tract had the highest
average ICAM-1 score while those originating from glandular tissues had the lowest average ICAM-1 score. Metastases localized in lymphoid
tissues had a higher average ICAM-1 score than those localized in non-lymphoid tissues. Since ICAM-1 is associated with a variety of cancer
types and appears to play a role in cancer metastasis, our findings should serve as a helpful resource for investigations of ICAM-1 as a
biomarker, as well as a target for therapeutic interventions. (IJCEP904001).
Key words: ICAM-1, immunohistochemistry, metastasis, tumor, tissue array
Full text PDF, Supplemental data
Address all correspondence to: Gail M. Seigel, Ph.D., Department of Ophthalmology, Ross Eye Institute, University at Buffalo, 3435 Main
Street, Sherman 124, Buffalo, NY 14214. Tel: 716-829-5216; Fax: 716-829-2344; Email: gseigel@frontiernet.net
Original Article
Immunoreactivity of ICAM-1 in Human Tumors, Metastases and Normal Tissues
Sarah H. Hayes and Gail M. Seigel
Department of Ophthalmology, Ross Eye Institute, University at Buffalo, Buffalo, NY
Received 06 April 2009; Accepted in revision 18 May 2009; Available online 10 June 2009
Abstract: Intercellular adhesion molecule-1 (ICAM-1) is implicated to play a role in cancer metastasis, and may serve as a diagnostic tool for
tumor prognosis and progression as well as a target for therapeutic intervention. The aim of this study was to carry out a comprehensive survey
of ICAM-1 immunoreactivity in normal, malignant and metastatic tissues. We assessed immunoreactivity of ICAM-1 in a total of 300 tissue
cores from multiple tissue arrays of normal, malignant, and metastatic tissues by immunohistochemistry. We scored tissue samples for
ICAM-1 immunoreactivity on a 0-3 scale, assessed the number of samples exhibiting infiltrating immune cells, and documented ICAM-1
immunoreactivity in some specific cell types. ICAM-1 expression in normal tissues was highest in spleen and absent in the cerebrum,
peripheral nerves, pancreas, ovary, breast, uterus, cervix, prostate, lung, larynx, bone marrow, striated muscle, heart, mesothelium,
esophagus, small intestine, colon and liver. In primary malignancies, lymphoid tissues received the highest average ICAM-1 score while
connective tissue/skin had the lowest average ICAM-1 score. Of the metastatic tissues, those originating from the urinary tract had the highest
average ICAM-1 score while those originating from glandular tissues had the lowest average ICAM-1 score. Metastases localized in lymphoid
tissues had a higher average ICAM-1 score than those localized in non-lymphoid tissues. Since ICAM-1 is associated with a variety of cancer
types and appears to play a role in cancer metastasis, our findings should serve as a helpful resource for investigations of ICAM-1 as a
biomarker, as well as a target for therapeutic interventions. (IJCEP904001).
Key words: ICAM-1, immunohistochemistry, metastasis, tumor, tissue array
Full text PDF, Supplemental data
Address all correspondence to: Gail M. Seigel, Ph.D., Department of Ophthalmology, Ross Eye Institute, University at Buffalo, 3435 Main
Street, Sherman 124, Buffalo, NY 14214. Tel: 716-829-5216; Fax: 716-829-2344; Email: gseigel@frontiernet.net
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