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Int J Clin Exp Pathol 2010;3(1):69-74
Original Article
Plugs clog the glandular outlets in fundic gland polyps
Carlos A. Rubio
Gastrointestinal and Liver Pathology Research Laboratory, Department of Pathology, Karolinska Institute and University Hospital, Stockholm,
Sweden
Received April 22, 2009; Accepted May 22, 2009; Available online July 20 2009
Abstract: A systematic histologic analysis of 62 gastric fundic gland polyps (FGP) was carried out. All FGP (100%) showed foveolar cells with
hypertrophic cytoplasm. In 95% of the FGP, parietal cells ballooned into the lumen and in 93%, exfoliated anucleated structures with
eosinophilic granules were found. Plugs of anucleated structures with eosinophilic granules, most likely derived from exfoliated parietal cells,
were found to clog the outlets of the glands in 86% of the FGP. None of the 30 control gastric biopsies without FGP had similar cellular
aberrations. FGP seems to evolve by cellular aberrations affecting parietal cells. This is not surprising considering that genetic mutations are
recorded in FGP with a common APC/b-catenin pathway in both FAP and sporadic cases. The genetic mutations in FGP might alter the
biological behavior of the parietal cells, leading to increased exfoliation with clogging of the outlets of the glands. Thus, the blocking of the
glandular outflow by plugs of anucleated structures with eosinophilic granules is the most likely cause for the cystic accumulation of “normal”
glandular secretions. (IJCEP904010).
Key Words: Fundic gland polyps, eosinophilic plugs, cystic formations
Full text PDF
Address all correspondence to:
Carlos A. Rubio, MD, PhD
Gastrointestinal and Liver Pathology Research Laboratory
Department of Pathology
Karolinska Institute and University Hospital
Stockholm, Sweden
E-mail: Carlos.Rubio@ki.se
Original Article
Plugs clog the glandular outlets in fundic gland polyps
Carlos A. Rubio
Gastrointestinal and Liver Pathology Research Laboratory, Department of Pathology, Karolinska Institute and University Hospital, Stockholm,
Sweden
Received April 22, 2009; Accepted May 22, 2009; Available online July 20 2009
Abstract: A systematic histologic analysis of 62 gastric fundic gland polyps (FGP) was carried out. All FGP (100%) showed foveolar cells with
hypertrophic cytoplasm. In 95% of the FGP, parietal cells ballooned into the lumen and in 93%, exfoliated anucleated structures with
eosinophilic granules were found. Plugs of anucleated structures with eosinophilic granules, most likely derived from exfoliated parietal cells,
were found to clog the outlets of the glands in 86% of the FGP. None of the 30 control gastric biopsies without FGP had similar cellular
aberrations. FGP seems to evolve by cellular aberrations affecting parietal cells. This is not surprising considering that genetic mutations are
recorded in FGP with a common APC/b-catenin pathway in both FAP and sporadic cases. The genetic mutations in FGP might alter the
biological behavior of the parietal cells, leading to increased exfoliation with clogging of the outlets of the glands. Thus, the blocking of the
glandular outflow by plugs of anucleated structures with eosinophilic granules is the most likely cause for the cystic accumulation of “normal”
glandular secretions. (IJCEP904010).
Key Words: Fundic gland polyps, eosinophilic plugs, cystic formations
Full text PDF
Address all correspondence to:
Carlos A. Rubio, MD, PhD
Gastrointestinal and Liver Pathology Research Laboratory
Department of Pathology
Karolinska Institute and University Hospital
Stockholm, Sweden
E-mail: Carlos.Rubio@ki.se
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